Muscarinic toxin 1

Muscarinic toxin 1 (MT1) belongs to the family of small peptides of 65 amino acid residues derived from the venom of African mamba snakes (Dendroaspis angusticeps), with dual specificity for muscarinic receptor subtypes M1 (Ki=20–35 nM)[1] and M4 (Ki=30–72 nM).[1] Muscarinic toxins like the nicotinic toxins have the three-finger fold structure, characteristic of the large superfamily of toxins that act at cholinergic synapses.

Muscarinic toxin 1

Crystal structure of the muscarinic toxin MT1(MT1) from PDB 4DO8 [2] [3]
Identifiers
Symbol MT1
SCOP 1F94
SUPERFAMILY 1F94

References

  1. 1 2 Servent, Denis; Blanchet, Guillaume; Mourier, Gilles; Marquer,Catherine; Marcon,Elodie; Fruchart-Gaillard, Carole (August 2011). "Muscarinic toxins". Toxicon 58 (6-7): 455–463. doi:10.1016/j.toxicon.2011.08.004. PMID 21906611.
  2. ↑ Fruchart-Gaillard, C., Mourier, G., Blanchet, G., Vera, L., Gilles, N., Menez, R., Marcon, E., Stura, E.A., Servent, D. (June 2012). "Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors". PLoS ONE 7 (6): e39166. doi:10.1371/journal.pone.0039166. PMID 22720062.
  3. ↑ Fruchart-Gaillard, C., Mournier, G., Vera, L., Servent, D., Stura, E.A. ["http://www.rcsb.org/pdb/explore/explore.do?structureId=4DO8" "Crystal structure of the muscarinic toxin MT1"].
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