Mycocerosate synthase

mycocerosate synthase
Identifiers
EC number	2.3.1.111
CAS number	95229-19-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a mycocerosate synthase (EC 2.3.1.111) is an enzyme that catalyzes the chemical reaction

acyl-CoA + n methylmalonyl-CoA + 2n NADPH + 2n H⁺ $\rightleftharpoons$ multi-methyl-branched acyl-CoA + n CoA + n CO₂ + 2n NADP⁺

The 4 substrates of this enzyme are acyl-CoA, methylmalonyl-CoA, NADPH, and H⁺, whereas its 4 products are multi-methyl-branched acyl-CoA, CoA, CO₂, and NADP⁺.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). This enzyme is also called mycocerosic acid synthase.

References

• Rainwater DL, Kolattukudy PE (1985). "Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA". J. Biol. Chem. 260 (1): 616–23. PMID 3880746.