Mycothione reductase

mycothione reductase
Identifiers
EC number 1.8.1.15
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a mycothione reductase (EC 1.8.1.15) is an enzyme that catalyzes the chemical reaction

mycothione + NAD(P)H + H + \rightleftharpoons 2 mycothiol + NADP+

in M. tuberculosis and other actinomycetes.

The 2 substrates of this enzyme are mycothiol and NADPH, whereas 2 molecules of mycothione and NADP+ are formed as products.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is mycothiol:NAD(P)+ oxidoreductase. This enzyme is also called mycothiol-disulfide reductase.

References

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