N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
Identifiers
EC number	2.8.2.33
CAS number	242469-38-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (EC 2.8.2.33, GalNAc4S-6ST, CHST15 (gene)) is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase.^[1][2] This enzyme catalyses the following chemical reaction

(1) 3-phospho-5-adenylyl sulfate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine $\rightleftharpoons$ adenosine 3',5'-bisphosphate + [dermatan]-4,6-di-O-sulfo-N-acetyl-D-galactosamine

(2) 3-phospho-5-adenylyl sulfate + [chondroitin]-4-O-sulfo-N-acetyl-D-galactosamine $\rightleftharpoons$ adenosine 3',5'-bisphosphate + [chondroitin]-4,6-di-O-sulfo-N-acetyl-D-galactosamine

The enzyme is activated by divalent cations and reduced glutathione.

References

1. Ito, Y. and Habuchi, O. (2000). "Purification and characterization of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase from the squid cartilage". J. Biol. Chem. 275 (44): 34728–34736. doi:10.1074/jbc.M909633199. PMID 10871629.
2. Ohtake, S., Ito, Y., Fukuta, M. and Habuchi, O. (2001). "Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene". J. Biol. Chem. 276: 43894–43900. doi:10.1074/jbc.M104922200. PMID 11572857.

External links

• N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)