N1-acetylpolyamine oxidase

N^1-acetylpolyamine oxidase
Identifiers
EC number	1.5.3.13
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

N¹-acetylpolyamine oxidase (EC 1.5.3.13, hPAO-1, mPAO, hPAO) is an enzyme with systematic name N¹-acetylpolyamine:oxygen oxidoreductase (3-acetamidopropanal-forming).^[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) N¹-acetylspermidine + O₂ + H₂O $\rightleftharpoons$ putrescine + 3-acetamidopropanal + H₂O₂

(2) N¹-acetylspermine + O₂ + H₂O $\rightleftharpoons$ spermidine + 3-acetamidopropanal + H₂O₂

This enzyme also catalyses the reaction:

N¹,N¹²-diacetylspermine + O₂ + H₂O $\rightleftharpoons$ N₁-acetylspermidine + 3-acetamamidopropanal + H₂O₂.

References

1. Vujcic, S., Liang, P., Diegelman, P., Kramer, D.L. and Porter, C.W. (2003). "Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion". Biochem. J. 370: 19–28. doi:10.1042/BJ20021779. PMC 1223169. PMID 12477380.
2. Jarvinen, A., Grigorenko, N., Khomutov, A.R., Hyvonen, M.T., Uimari, A., Vepsalainen, J., Sinervirta, R., Keinanen, T.A., Vujcic, S., Alhonen, L., Porter, C.W. and Janne, J. (2005). "Metabolic stability of α-methylated polyamine derivatives and their use as substitutes for the natural polyamines". J. Biol. Chem. 280 (8): 6595–6601. doi:10.1074/jbc.M412788200. PMID 15611107.
3. Wang, Y., Hacker, A., Murray-Stewart, T., Frydman, B., Valasinas, A., Fraser, A.V., Woster, P.M. and Casero, R.A., Jr. (2005). "Properties of recombinant human N¹-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity". Cancer Chemother. Pharmacol. 56 (1): 83–90. doi:10.1007/s00280-004-0936-5. PMID 15791459.
4. Wu, T., Yankovskaya, V. and McIntire, W.S. (2003). "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N¹-acetylated polyamine oxidase". J. Biol. Chem. 278: 20514–20525. doi:10.1074/jbc.M302149200. PMID 12660232.

External links

• N1-acetylpolyamine oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)