BTBD14B

Nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3GA1​, 4U2N​
Identifiers
Symbols	NACC1 ; BEND8; BTBD14B; BTBD30; NAC-1; NAC1
External IDs	OMIM: 610672 MGI: 1914080 HomoloGene: 12042 GeneCards: NACC1 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Cellular component • nucleus • nucleoplasm • cytoplasm • nuclear body • cell junction • intracellular membrane-bounded organelle Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • positive regulation of cell proliferation • negative regulation of transcription, DNA-templated • protein homooligomerization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	112939	66830
Ensembl	ENSG00000160877	ENSMUSG00000001910
UniProt	Q96RE7	Q7TSZ8
RefSeq (mRNA)	NM_052876	NM_025788
RefSeq (protein)	NP_443108	NP_080064
Location (UCSC)	Chr 19: 13.12 – 13.14 Mb	Chr 8: 84.67 – 84.69 Mb
PubMed search

Nucleus accumbens-associated protein 1 is a protein that in humans is encoded by the NACC1 gene.^[1][2]

References

1. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
2. "Entrez Gene: BTBD14B BTB (POZ) domain containing 14B".

l

Further reading

• Nakayama K, Nakayama N, Wang TL, Shih IeM (2007). "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor". Cancer Res. 67 (17): 8058–64. doi:10.1158/0008-5472.CAN-07-1357. PMID 17804717.
• Davidson B, Berner A, Trope' CG, et al. (2007). "Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions". Hum. Pathol. 38 (7): 1030–6. doi:10.1016/j.humpath.2006.12.009. PMID 17391728.
• Nakayama K, Nakayama N, Davidson B, et al. (2007). "A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival". Proc. Natl. Acad. Sci. U.S.A. 103 (49): 18739–44. doi:10.1073/pnas.0604083103. PMC 1693732. PMID 17130457.
• Korutla L, Wang PJ, Mackler SA (2005). "The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures". J. Neurochem. 94 (3): 786–93. doi:10.1111/j.1471-4159.2005.03206.x. PMID 16033423.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Korutla L, Wang PJ, Lewis DM, et al. (2002). "Differences in expression, actions and cocaine regulation of two isoforms for the brain transcriptional regulator NAC1". Neuroscience 110 (3): 421–9. doi:10.1016/S0306-4522(01)00518-8. PMID 11906783.