NANOS1

Nanos homolog 1 (Drosophila)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4CQO​
Identifiers
Symbols	NANOS1 ; NOS1; SPGF12
External IDs	OMIM: 608226 HomoloGene: 131234 GeneCards: NANOS1 Gene
Gene ontology Molecular function • RNA binding • protein binding • zinc ion binding • translation repressor activity Cellular component • cytoplasm • perinuclear region of cytoplasm Biological process • epithelial cell migration • cell migration • negative regulation of translation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	340719	332397
Ensembl	ENSG00000188613	ENSMUSG00000072437
UniProt	Q8WY41	Q80WY3
RefSeq (mRNA)	NM_001009553	NM_178421
RefSeq (protein)	NP_955631	NP_848508
Location (UCSC)	Chr 10: 119.03 – 119.03 Mb	Chr 19: 60.76 – 60.76 Mb
PubMed search

Nanos homolog 1 (Drosophila) is a protein that in humans is encoded by the NANOS1 gene. ^[1]

References

1. "Entrez Gene: Nanos homolog 1 (Drosophila)". Retrieved 2014-10-31.

Further reading

• Bonnomet, A; Polette, M; Strumane, K; Gilles, C; Dalstein, V; Kileztky, C; Berx, G; Van Roy, F; Birembaut, P; Nawrocki-Raby, B (2008). "The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression". Oncogene 27 (26): 3692–9. doi:10.1038/sj.onc.1211035. PMID 18223680.
• Lu, C; Xu, M; Wang, Y; Qin, Y; Du, G; Wu, W; Han, X; Ji, C; Yang, Y; Gu, A; Xia, Y; Song, L; Wang, S; Wang, X (2013). "Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population". PLoS ONE 8 (1): e53443. doi:10.1371/journal.pone.0053443. PMC 3540065. PMID 23320086.
• Kusz-Zamelczyk, K; Sajek, M; Spik, A; Glazar, R; Jędrzejczak, P; Latos-Bieleńska, A; Kotecki, M; Pawelczyk, L; Jaruzelska, J (2013). "Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia". Journal of Medical Genetics 50 (3): 187–93. doi:10.1136/jmedgenet-2012-101230. PMID 23315541.
• Ginter-Matuszewska, B; Kusz, K; Spik, A; Grzeszkowiak, D; Rembiszewska, A; Kupryjanczyk, J; Jaruzelska, J (2011). "NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells". Histochemistry and Cell Biology 136 (3): 279–87. doi:10.1007/s00418-011-0842-y. PMID 21800163.
• Strumane, K; Bonnomet, A; Stove, C; Vandenbroucke, R; Nawrocki-Raby, B; Bruyneel, E; Mareel, M; Birembaut, P; Berx, G; Van Roy, F (2006). "E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion". Cancer Research 66 (20): 10007–15. doi:10.1158/0008-5472.CAN-05-3096. PMID 17047063.
• Kurokawa, H; Aoki, Y; Nakamura, S; Ebe, Y; Kobayashi, D; Tanaka, M (2006). "Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes". Development, Growth and Differentiation 48 (3): 209–21. doi:10.1111/j.1440-169X.2006.00858.x. PMID 16573738.
• Jaruzelska, J; Kotecki, M; Kusz, K; Spik, A; Firpo, M; Reijo Pera, R. A. (2003). "Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells". Development genes and evolution 213 (3): 120–6. doi:10.1007/s00427-003-0303-2 (inactive 2015-02-28). PMID 12690449.
• Ginter-Matuszewska, B; Spik, A; Rembiszewska, A; Koyias, C; Kupryjanczyk, J; Jaruzelska, J (2009). "The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells". Molecular Human Reproduction 15 (3): 173–9. doi:10.1093/molehr/gap004. PMID 19168546.
• Husi, H; Ward, M. A.; Choudhary, J. S.; Blackstock, W. P.; Grant, S. G. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.