NBR1

Neighbor of BRCA1 gene 1
PDB rendering based on 1wj6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1WJ6​, 2BKF​, 2CP8​, 2G4S​, 2L8J​, 2MGW​, 2MJ5​, 4OLE​
Identifiers
Symbols	NBR1 ; 1A1-3B; IAI3B; M17S2; MIG19
External IDs	OMIM: 166945 MGI: 108498 HomoloGene: 7438 GeneCards: NBR1 Gene
Gene ontology Molecular function • protein binding • zinc ion binding • ubiquitin binding • mitogen-activated protein kinase binding Cellular component • pre-autophagosomal structure • mitochondrion • lysosome • late endosome • autophagosome • cytosol • membrane • cytoplasmic vesicle • M band • extracellular exosome Biological process • macroautophagy • regulation of bone mineralization • regulation of stress-activated MAPK cascade • negative regulation of osteoblast differentiation • protein oligomerization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4077	17966
Ensembl	ENSG00000188554	ENSMUSG00000017119
UniProt	Q14596	P97432
RefSeq (mRNA)	NM_001291571	NM_001252220
RefSeq (protein)	NP_001278500	NP_001239149
Location (UCSC)	Chr 17: 43.17 – 43.21 Mb	Chr 11: 101.55 – 101.58 Mb
PubMed search

Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.^[1][2]

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.^[2] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.^[3]

Interactions

NBR1 has been shown to interact with FEZ1.^[4]

References

1. Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304.
2. "Entrez Gene: NBR1 neighbor of BRCA1 gene 1".
3. Kirkin, Vladimir (2009). "A Role for Ubiquitin in Selective Autophagy". Molecular Cell 34: 259–269. doi:10.1016/j.molcel.2009.04.026.
4. Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. (Germany) 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312.

Further reading

• Miki Y, Swensen J, Shattuck-Eidens D, et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science 266 (5182): 66–71. doi:10.1126/science.7545954. PMID 7545954.
• Harshman K, Bell R, Rosenthal J, et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259–1266. doi:10.1093/hmg/4.8.1259. PMID 7581362.
• Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–229. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Brown MA, Nicolai H, Xu CF, et al. (1995). "Regulation of BRCA1". Nature 372 (6508): 733–733. doi:10.1038/372733a0. PMID 7997258.
• Brown MA, Xu CF, Nicolai H, et al. (1996). "The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21". Oncogene 12 (12): 2507–13. PMID 8700509.
• Dimitrov S, Brennerova M, Forejt J (2001). "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes". Gene 262 (1–2): 89–98. doi:10.1016/S0378-1119(00)00549-7. PMID 11179671.
• Whitehouse C, Chambers J, Howe K, et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312.
• Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lamark T, Perander M, Outzen H, et al. (2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins". J. Biol. Chem. 278 (36): 34568–34581. doi:10.1074/jbc.M303221200. PMID 12813044.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lange S, Xiang F, Yakovenko A, et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science 308 (5728): 1599–1603. doi:10.1126/science.1110463. PMID 15802564.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.