NCKAP1

NCK-associated protein 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3P8C​, 4N78​
Identifiers
Symbols	NCKAP1 ; HEM2; NAP1; NAP125; p125Nap1
External IDs	OMIM: 604891 MGI: 1355333 HomoloGene: 8384 GeneCards: NCKAP1 Gene
Gene ontology Molecular function • protein binding • protein complex binding • Rac GTPase binding Cellular component • cytosol • focal adhesion • integral component of membrane • SCAR complex • lamellipodium membrane • extracellular exosome Biological process • in utero embryonic development • somitogenesis • neural tube closure • apoptotic process • small GTPase mediated signal transduction • zygotic determination of anterior/posterior axis, embryo • central nervous system development • endoderm development • mesodermal cell migration • embryonic body morphogenesis • positive regulation of lamellipodium assembly • viral process • Rac protein signal transduction • lamellipodium assembly • establishment or maintenance of actin cytoskeleton polarity • regulation of protein localization • embryonic heart tube development • Fc-gamma receptor signaling pathway involved in phagocytosis • cell migration involved in gastrulation • innate immune response • basal protein localization • apical protein localization • vascular endothelial growth factor receptor signaling pathway • paraxial mesoderm morphogenesis • notochord morphogenesis • embryonic foregut morphogenesis • protein stabilization • positive regulation of Arp2/3 complex-mediated actin nucleation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10787	50884
Ensembl	ENSG00000061676	ENSMUSG00000027002
UniProt	Q9Y2A7	P28660
RefSeq (mRNA)	NM_013436	NM_001290745
RefSeq (protein)	NP_038464	NP_001277674
Location (UCSC)	Chr 2: 182.91 – 183.04 Mb	Chr 2: 80.5 – 80.58 Mb
PubMed search

Nck-associated protein 1 is a protein that in humans is encoded by the NCKAP1 gene.^[1][2][3][4]

Interactions

NCKAP1 has been shown to interact with RAC1^[5] and ABI1.^[6]

References

1. Suzuki T, Nishiyama K, Yamamoto A, Inazawa J, Iwaki T, Yamada T, Kanazawa I, Sakaki Y (Jan 2000). "Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease". Genomics 63 (2): 246–54. doi:10.1006/geno.1999.6053. PMID 10673335.
2. Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW (Aug 2002). "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck". Nature 418 (6899): 790–3. doi:10.1038/nature00859. PMID 12181570.
3. Matuoka K, Miki H, Takahashi K, Takenawa T (Oct 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochemical and Biophysical Research Communications 239 (2): 488–92. doi:10.1006/bbrc.1997.7492. PMID 9344857.
4. "Entrez Gene: NCKAP1 NCK-associated protein 1".
5. Kitamura Y, Kitamura T, Sakaue H, Maeda T, Ueno H, Nishio S, Ohno S, Osada SI, Sakaue M, Ogawa W, Kasuga M (Mar 1997). "Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac". The Biochemical Journal. 322 ( Pt 3) (Pt 3): 873–8. PMC 1218269. PMID 9148763.
6. Yamamoto A, Suzuki T, Sakaki Y (Jun 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.

Further reading

• Kitamura T, Kitamura Y, Yonezawa K, Totty NF, Gout I, Hara K, Waterfield MD, Sakaue M, Ogawa W, Kasuga M (Feb 1996). "Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck". Biochemical and Biophysical Research Communications 219 (2): 509–14. doi:10.1006/bbrc.1996.0264. PMID 8605018.
• Kobayashi K, Kuroda S, Fukata M, Nakamura T, Nagase T, Nomura N, Matsuura Y, Yoshida-Kubomura N, Iwamatsu A, Kaibuchi K (Jan 1998). "p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase". The Journal of Biological Chemistry 273 (1): 291–5. doi:10.1074/jbc.273.1.291. PMID 9417078.
• Witke W, Podtelejnikov AV, Di Nardo A, Sutherland JD, Gurniak CB, Dotti C, Mann M (Feb 1998). "In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly". The EMBO Journal 17 (4): 967–76. doi:10.1093/emboj/17.4.967. PMC 1170446. PMID 9463375.
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Yamamoto A, Suzuki T, Sakaki Y (Jun 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.
• Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, Serna DM, Sondek J, Gertler FB, De Camilli P (Dec 2003). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton". The Journal of Biological Chemistry 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
• Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M (Nov 2003). "Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling". Molecular and Cellular Biology 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMC 207563. PMID 14560022.
• Innocenti M, Zucconi A, Disanza A, Frittoli E, Areces LB, Steffen A, Stradal TE, Di Fiore PP, Carlier MF, Scita G (Apr 2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". Nature Cell Biology 6 (4): 319–27. doi:10.1038/ncb1105. PMID 15048123.
• Mayne M, Moffatt T, Kong H, McLaren PJ, Fowke KR, Becker KG, Namaka M, Schenck A, Bardoni B, Bernstein CN, Melanson M (Apr 2004). "CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion". European Journal of Immunology 34 (4): 1217–27. doi:10.1002/eji.200324726. PMID 15048733.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Chen W, Tang Z, Fortina P, Patel P, Addya S, Surrey S, Acheampong EA, Mukhtar M, Pomerantz RJ (Mar 2005). "Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways". Virology 334 (1): 59–73. doi:10.1016/j.virol.2005.01.014. PMID 15749123.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.