NDE1

NudE neurodevelopment protein 1
Identifiers
Symbols	NDE1 ; HOM-TES-87; LIS4; MHAC; NDE; NUDE; NUDE1
External IDs	OMIM: 609449 HomoloGene: 32354 GeneCards: NDE1 Gene
Gene ontology Molecular function • protein binding • microtubule binding • protein domain specific binding • identical protein binding Cellular component • kinetochore • condensed chromosome kinetochore • centrosome • cytosol • kinesin complex • microtubule • membrane • spindle pole centrosome • cleavage furrow Biological process • G2/M transition of mitotic cell cycle • establishment of mitotic spindle orientation • mitotic cell cycle • neuron migration • organelle organization • microtubule nucleation • chromosome segregation • mitotic centrosome separation • small GTPase mediated signal transduction • neuroblast proliferation • cell migration • cerebral cortex development • vesicle transport along microtubule • centrosome duplication • cell division • establishment of chromosome localization • centrosome localization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54820	67203
Ensembl	ENSG00000072864	ENSMUSG00000022678
UniProt	Q9NXR1	Q9CZA6
RefSeq (mRNA)	NM_001143979	NM_001114085
RefSeq (protein)	NP_001137451	NP_001107557
Location (UCSC)	Chr 16: 15.64 – 15.73 Mb	Chr 16: 14.16 – 14.19 Mb
PubMed search

Nuclear distribution protein nudE homolog 1 is a protein that in humans is encoded by the NDE1 gene.^[1][2][3]

References

1. Kitagawa M, Umezu M, Aoki J, Koizumi H, Arai H, Inoue K (Sep 2000). "Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE". FEBS Lett 479 (1–2): 57–62. doi:10.1016/S0014-5793(00)01856-1. PMID 10940388.
2. Meyer G, Perez-Garcia CG, Gleeson JG (Nov 2002). "Selective expression of doublecortin and LIS1 in developing human cortex suggests unique modes of neuronal movement". Cereb Cortex 12 (12): 1225–36. doi:10.1093/cercor/12.12.1225. PMID 12427674.
3. "Entrez Gene: NDE1 nudE nuclear distribution gene E homolog 1 (A. nidulans)".

Further reading

• Feng Y, Olson EC, Stukenberg PT, et al. (2001). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron 28 (3): 665–79. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258.
• Türeci O, Sahin U, Koslowski M, et al. (2002). "A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing". Oncogene 21 (24): 3879–88. doi:10.1038/sj.onc.1205481. PMID 12032826.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yan X, Li F, Liang Y, et al. (2003). "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle". Mol. Cell. Biol. 23 (4): 1239–50. doi:10.1128/MCB.23.4.1239-1250.2003. PMC 141156. PMID 12556484.
• Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. doi:10.1016/j.bbrc.2003.10.101. PMID 14623284.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
• Brandon NJ, Schurov I, Camargo LM, et al. (2005). "Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site". Mol. Cell. Neurosci. 28 (4): 613–24. doi:10.1016/j.mcn.2004.11.003. PMID 15797709.
• Guo J, Yang Z, Song W, et al. (2006). "Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly". Mol. Biol. Cell 17 (2): 680–9. doi:10.1091/mbc.E05-04-0360. PMC 1356579. PMID 16291865.
• Hirohashi Y, Wang Q, Liu Q, et al. (2006). "Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation". Oncogene 25 (45): 6048–55. doi:10.1038/sj.onc.1209637. PMID 16682949.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Hennah W, Tomppo L, Hiekkalinna T, et al. (2007). "Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1". Hum. Mol. Genet. 16 (5): 453–62. doi:10.1093/hmg/ddl462. PMID 17185386.