NDEL1

NudE neurodevelopment protein 1-like 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2V66​
Identifiers
Symbols	NDEL1 ; EOPA; MITAP1; NDE1L1; NDE2; NUDEL
External IDs	OMIM: 607538 MGI: 1932915 HomoloGene: 32567 GeneCards: NDEL1 Gene
Gene ontology Molecular function • protein binding • microtubule binding • alpha-tubulin binding • beta-tubulin binding • oligopeptidase activity Cellular component • kinetochore • condensed chromosome kinetochore • nuclear envelope • nucleolus • cytoplasm • centrosome • spindle • cytosol • kinesin complex • microtubule • cell leading edge • axon hillock • neurofilament cytoskeleton Biological process • establishment of mitotic spindle orientation • mitotic cell cycle • neuron migration • inner cell mass cell proliferation • proteolysis • microtubule nucleation • chromosome segregation • mitotic centrosome separation • small GTPase mediated signal transduction • retrograde axon cargo transport • regulation of neuron projection development • cell migration • cerebral cortex radially oriented cell migration • central nervous system neuron axonogenesis • regulation of intracellular protein transport • positive regulation of GTPase activity • positive regulation of axon extension • vesicle transport along microtubule • positive regulation of axon regeneration • nuclear envelope disassembly • establishment of chromosome localization • centrosome localization • neurofilament cytoskeleton organization • activation of GTPase activity • neuron projection extension Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81565	83431
Ensembl	ENSG00000166579	ENSMUSG00000018736
UniProt	Q9GZM8	Q9ERR1
RefSeq (mRNA)	NM_001025579	NM_023668
RefSeq (protein)	NP_001020750	NP_076157
Location (UCSC)	Chr 17: 8.41 – 8.49 Mb	Chr 11: 68.82 – 68.87 Mb
PubMed search

Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.^[1][2][3]

This gene encodes a thiol-activated oligopeptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[3]

Interactions

NDEL1 has been shown to interact with Cyclin-dependent kinase 5,^[1] YWHAE,^[4] PAFAH1B1^[1][4] and DISC1.^[5][6]

References

1. Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH (Dec 2000). "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein". Neuron 28 (3): 697–711. doi:10.1016/S0896-6273(00)00147-1. PMID 11163260.
2. Sasaki S, Shionoya A, Ishida M, Gambello MJ, Yingling J, Wynshaw-Boris A, Hirotsune S (Dec 2000). "A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system". Neuron 28 (3): 681–96. doi:10.1016/S0896-6273(00)00146-X. PMID 11163259.
3. "Entrez Gene: NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1".
4. Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A (Jul 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nature Genetics 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778.
5. Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Human Molecular Genetics 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
6. Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten ME, Snyder SH, Ross CA, Sawa A (Jan 2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proceedings of the National Academy of Sciences of the United States of America 100 (1): 289–94. doi:10.1073/pnas.0136913100. PMC 140954. PMID 12506198.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA (Dec 2000). "LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome". Neuron 28 (3): 665–79. doi:10.1016/S0896-6273(00)00145-8. PMID 11163258.
• Ozeki Y, Tomoda T, Kleiderlein J, Kamiya A, Bord L, Fujii K, Okawa M, Yamada N, Hatten ME, Snyder SH, Ross CA, Sawa A (Jan 2003). "Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth". Proceedings of the National Academy of Sciences of the United States of America 100 (1): 289–94. doi:10.1073/pnas.0136913100. PMC 140954. PMID 12506198.
• Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, Zhu X (Feb 2003). "Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle". Molecular and Cellular Biology 23 (4): 1239–50. doi:10.1128/MCB.23.4.1239-1250.2003. PMC 141156. PMID 12556484.
• Cardoso C, Leventer RJ, Ward HL, Toyo-Oka K, Chung J, Gross A, Martin CL, Allanson J, Pilz DT, Olney AH, Mutchinick OM, Hirotsune S, Wynshaw-Boris A, Dobyns WB, Ledbetter DH (Apr 2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3". American Journal of Human Genetics 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583.
• Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, Hirotsune S, Wynshaw-Boris A (Jul 2003). "14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome". Nature Genetics 34 (3): 274–85. doi:10.1038/ng1169. PMID 12796778.
• Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Human Molecular Genetics 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
• Brandon NJ, Handford EJ, Schurov I, Rain JC, Pelling M, Duran-Jimeniz B, Camargo LM, Oliver KR, Beher D, Shearman MS, Whiting PJ (Jan 2004). "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders". Molecular and Cellular Neurosciences 25 (1): 42–55. doi:10.1016/j.mcn.2003.09.009. PMID 14962739.
• Liang Y, Yu W, Li Y, Yang Z, Yan X, Huang Q, Zhu X (Feb 2004). "Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein". The Journal of Cell Biology 164 (4): 557–66. doi:10.1083/jcb.200308058. PMC 2171987. PMID 14970193.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A (Dec 2004). "Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase". Neuron 44 (5): 809–21. doi:10.1016/j.neuron.2004.11.019. PMID 15572112.
• Hayashi MA, Portaro FC, Bastos MF, Guerreiro JR, Oliveira V, Gorrão SS, Tambourgi DV, Sant'Anna OA, Whiting PJ, Camargo LM, Konno K, Brandon NJ, Camargo AC (Mar 2005). "Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1". Proceedings of the National Academy of Sciences of the United States of America 102 (10): 3828–33. doi:10.1073/pnas.0500330102. PMC 553309. PMID 15728732.
• Guerreiro JR, Winnischofer SM, Bastos MF, Portaro FC, Sogayar MC, de Camargo AC, Hayashi MA (Jul 2005). "Cloning and characterization of the human and rabbit NUDEL-oligopeptidase promoters and their negative regulation". Biochimica Et Biophysica Acta 1730 (1): 77–84. doi:10.1016/j.bbaexp.2005.06.001. PMID 16005531.