NDRG1

N-myc downstream regulated 1
Identifiers
Symbols	NDRG1 ; CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5
External IDs	OMIM: 605262 MGI: 1341799 HomoloGene: 55953 GeneCards: NDRG1 Gene
Gene ontology Molecular function • protein binding • microtubule binding • Rab GTPase binding • gamma-tubulin binding • cadherin binding Cellular component • nucleus • cytoplasm • centrosome • cytosol • microtubule • plasma membrane • cell-cell adherens junction • microtubule cytoskeleton • myelin sheath • perinuclear region of cytoplasm • recycling endosome membrane • extracellular exosome Biological process • negative regulation of cell proliferation • response to metal ion • DNA damage response, signal transduction by p53 class mediator • peripheral nervous system myelin maintenance • mast cell activation • cellular response to hypoxia • positive regulation of spindle checkpoint Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10397	17988
Ensembl	ENSG00000104419	ENSMUSG00000005125
UniProt	Q92597	Q62433
RefSeq (mRNA)	NM_001135242	NM_008681
RefSeq (protein)	NP_001128714	NP_032707
Location (UCSC)	Chr 8: 133.24 – 133.3 Mb	Chr 15: 66.93 – 66.97 Mb
PubMed search

Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene.^[1][2][3][4]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation . Mutations in this gene have been reported to be causative the autosomal-recessive version of Charcot-Marie-Tooth disease known as CMT4D.^[4] It has been reported that NDRG1 localizes to the endosomes and is a Rab4a effector involved in vesicular recycling.^[5]

References

1. van Belzen N, Dinjens WN, Diesveld MP, Groen NA, van der Made AC, Nozawa Y, Vlietstra R, Trapman J, Bosman FT (Sep 1997). "A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms". Lab Invest 77 (1): 85–92. PMID 9251681.
2. Kokame K, Kato H, Miyata T (Jan 1997). "Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes". J Biol Chem 271 (47): 29659–65. doi:10.1074/jbc.271.47.29659. PMID 8939898.
3. Zhang J, Chen S, Zhang W, Zhang J, Liu X, Shi H, Che H, Wang W, Li F, Yao L (Jun 2008). "Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region". Gene 417 (1-2): 5–12. doi:10.1016/j.gene.2008.03.002. PMID 18455888.
4. "Entrez Gene: NDRG1 N-myc downstream regulated gene 1".
5. Kachhap SK, Faith D, Qian DZ, et al. (2007). Heisenberg CP, ed. "The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin". PLoS ONE 2 (9): e844. doi:10.1371/journal.pone.0000844. PMC 1952073. PMID 17786215.

Further reading

• Kovacevic Z, Richardson DR (2007). "The metastasis suppressor, Ndrg-1: a new ally in the fight against cancer.". Carcinogenesis 27 (12): 2355–66. doi:10.1093/carcin/bgl146. PMID 16920733.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Kalaydjieva L, Hallmayer J, Chandler D, et al. (1996). "Gene mapping in Gypsies identifies a novel demyelinating neuropathy on chromosome 8q24.". Nat. Genet. 14 (2): 214–7. doi:10.1038/ng1096-214. PMID 8841199.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhou D, Salnikow K, Costa M (1998). "Cap43, a novel gene specifically induced by Ni2+ compounds.". Cancer Res. 58 (10): 2182–9. PMID 9605764.
• Kurdistani SK, Arizti P, Reimer CL, et al. (1998). "Inhibition of tumor cell growth by RTP/rit42 and its responsiveness to p53 and DNA damage.". Cancer Res. 58 (19): 4439–44. PMID 9766676.
• Piquemal D, Joulia D, Balaguer P, et al. (1999). "Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells.". Biochim. Biophys. Acta 1450 (3): 364–73. doi:10.1016/S0167-4889(99)00056-7. PMID 10395947.
• Guan RJ, Ford HL, Fu Y, et al. (2000). "Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer.". Cancer Res. 60 (3): 749–55. PMID 10676663.
• Kalaydjieva L, Gresham D, Gooding R, et al. (2000). "N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom.". Am. J. Hum. Genet. 67 (1): 47–58. doi:10.1086/302978. PMC 1287101. PMID 10831399.
• Park H, Adams MA, Lachat P, et al. (2000). "Hypoxia induces the expression of a 43-kDa protein (PROXY-1) in normal and malignant cells.". Biochem. Biophys. Res. Commun. 276 (1): 321–8. doi:10.1006/bbrc.2000.3475. PMID 11006124.
• Rutherford MN, Bayly GR, Matthews BP, et al. (2001). "The leukemogenic transcription factor E2a-Pbx1 induces expression of the putative N-myc and p53 target gene NDRG1 in Ba/F3 cells.". Leukemia 15 (3): 362–70. doi:10.1038/sj.leu.2402059. PMID 11237058.
• Zhou RH, Kokame K, Tsukamoto Y, et al. (2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart.". Genomics 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569.
• Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.". Mol. Cell. Biochem. 229 (1-2): 35–44. doi:10.1023/A:1017934810825. PMID 11936845.
• Cangul H, Salnikow K, Yee H, et al. (2002). "Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis.". Cell Biol. Toxicol. 18 (2): 87–96. doi:10.1023/A:1015376032736. PMID 12046693.
• Cangul H, Salnikow K, Yee H, et al. (2002). "Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells.". Environ. Health Perspect. 110 Suppl 5: 783–8. doi:10.1289/ehp.02110s5783. PMC 1241245. PMID 12429530.
• Lachat P, Shaw P, Gebhard S, et al. (2003). "Expression of NDRG1, a differentiation-related gene, in human tissues.". Histochem. Cell Biol. 118 (5): 399–408. doi:10.1007/s00418-002-0460-9. PMID 12432451.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Segawa T, Nau ME, Xu LL, et al. (2003). "Androgen-induced expression of endoplasmic reticulum (ER) stress response genes in prostate cancer cells.". Oncogene 21 (57): 8749–58. doi:10.1038/sj.onc.1205992. PMID 12483528.
• Symes, AJ, Eilertsen, M and Millar, M; et al. (2013). "Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue". PLoS ONE 8 (12): e84295. doi:10.1371/journal.pone.0084295. PMC 3874000. PMID 24386364.

External links

• GeneReviews/NCBI/NIH/UW entry on Charcot-Marie-Tooth Neuropathy Type 4