NDRG4

NDRG family member 4
Identifiers
Symbols	NDRG4 ; BDM1; SMAP-8; SMAP8
External IDs	OMIM: 614463 MGI: 2384590 HomoloGene: 23228 GeneCards: NDRG4 Gene
Gene ontology Molecular function • molecular_function • protein binding Cellular component • cytoplasm • mitochondrion • endoplasmic reticulum membrane • cytosol • basolateral plasma membrane • cell projection membrane Biological process • heart looping • response to stress • signal transduction • brain development • visual learning • negative regulation of platelet-derived growth factor receptor signaling pathway • positive regulation of neuron projection development • negative regulation of smooth muscle cell migration • cell growth • cell differentiation • embryonic heart tube development • vesicle docking • negative regulation of smooth muscle cell proliferation • cardiac muscle cell proliferation • cell migration involved in heart development • positive regulation of ERK1 and ERK2 cascade • regulation of endocytic recycling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	65009	234593
Ensembl	ENSG00000103034	ENSMUSG00000036564
UniProt	Q9ULP0	Q8BTG7
RefSeq (mRNA)	NM_001130487	NM_001195006
RefSeq (protein)	NP_001123959	NP_001181935
Location (UCSC)	Chr 16: 58.46 – 58.51 Mb	Chr 8: 95.68 – 95.72 Mb
PubMed search

Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene.^[1][2][3]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[3]

References

1. Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T (May 2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569.
2. Hongo S, Watanabe T, Takahashi K, Miyazaki A (Apr 2006). "Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation". J Cell Biochem 98 (1): 185–93. doi:10.1002/jcb.20763. PMID 16408304.
3. "Entrez Gene: NDRG4 NDRG family member 4".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol. Cell. Biochem. 229 (1–2): 35–44. doi:10.1023/A:1017934810825. PMID 11936845.
• Ohki T, Hongo S, Nakada N, et al. (2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells". Brain Res. Dev. Brain Res. 135 (1–2): 55–63. doi:10.1016/S0165-3806(02)00300-0. PMID 11978393.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nishimoto S, Tawara J, Toyoda H, et al. (2003). "A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells". Eur. J. Biochem. 270 (11): 2521–31. doi:10.1046/j.1432-1033.2003.03626.x. PMID 12755708.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.