NDST1

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
PDB rendering based on 1nst.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1NST​
Identifiers
Symbols	NDST1 ; HSST; MRT46; NST1
External IDs	OMIM: 600853 MGI: 104719 HomoloGene: 20386 GeneCards: NDST1 Gene
EC number	2.8.2.8
Gene ontology Molecular function • [heparan sulfate-glucosamine N-sulfotransferase activity] • deacetylase activity Cellular component • Golgi membrane • integral component of membrane Biological process • MAPK cascade • polysaccharide biosynthetic process • carbohydrate metabolic process • glycosaminoglycan biosynthetic process • inflammatory response • smoothened signaling pathway • respiratory gaseous exchange • fibroblast growth factor receptor signaling pathway • heparan sulfate proteoglycan biosynthetic process • glycosaminoglycan metabolic process • heparin biosynthetic process • forebrain development • midbrain development • small molecule metabolic process • embryonic neurocranium morphogenesis • embryonic viscerocranium morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3340	15531
Ensembl	ENSG00000070614	ENSMUSG00000054008
UniProt	P52848	Q3UHN9
RefSeq (mRNA)	NM_001301063	NM_008306
RefSeq (protein)	NP_001287992	NP_032332
Location (UCSC)	Chr 5: 150.49 – 150.56 Mb	Chr 18: 60.69 – 60.71 Mb
PubMed search

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.^[1][2][3]

References

1. Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ (Aug 1995). "Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1". Genomics 26 (2): 239–44. doi:10.1016/0888-7543(95)80206-2. PMID 7601448.
2. Humphries DE, Sullivan BM, Aleixo MD, Stow JL (Aug 1997). "Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network". Biochem J. 325. ( Pt 2): 351–7. PMC 1218567. PMID 9230113.
3. "Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1".

Further reading

• Sueyoshi T, Kakuta Y, Pedersen LC, et al. (1998). "A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase.". FEBS Lett. 433 (3): 211–4. doi:10.1016/S0014-5793(98)00913-2. PMID 9744796.
• Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family.". J. Biol. Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.
• Kakuta Y, Sueyoshi T, Negishi M, Pedersen LC (1999). "Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1.". J. Biol. Chem. 274 (16): 10673–6. doi:10.1074/jbc.274.16.10673. PMID 10196134.
• Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns.". Biochemistry 39 (15): 4552–8. doi:10.1021/bi992524l. PMID 10758005.
• Mura CV, Becker MI, Orellana A, Wolff D (2002). "Immunopurification of Golgi vesicles by magnetic sorting.". J. Immunol. Methods 260 (1-2): 263–71. doi:10.1016/S0022-1759(01)00546-4. PMID 11792394.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bengtsson J, Eriksson I, Kjellén L (2003). "Distinct effects on heparan sulfate structure by different active site mutations in NDST-1.". Biochemistry 42 (7): 2110–5. doi:10.1021/bi026928g. PMID 12590599.
• van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2.". Glycobiology 13 (1): 1–10. doi:10.1093/glycob/cwg011. PMID 12634318.
• Nakayama K, Natori Y, Sato T, et al. (2004). "Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis.". J. Lab. Clin. Med. 143 (2): 106–14. doi:10.1016/j.lab.2003.10.012. PMID 14966466.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.