NEDD1
| Neural precursor cell expressed, developmentally down-regulated 1 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | NEDD1 ; GCP-WD; TUBGCP7 | ||||||||||
| External IDs | OMIM: 600372 MGI: 97293 HomoloGene: 7439 GeneCards: NEDD1 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 121441 | 17997 | |||||||||
| Ensembl | ENSG00000139350 | ENSMUSG00000019988 | |||||||||
| UniProt | Q8NHV4 | P33215 | |||||||||
| RefSeq (mRNA) | NM_001135175 | NM_008682 | |||||||||
| RefSeq (protein) | NP_001128647 | NP_032708 | |||||||||
| Location (UCSC) |
Chr 12: 96.91 – 96.95 Mb |
Chr 10: 92.68 – 92.72 Mb | |||||||||
| PubMed search | |||||||||||
Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene [1] and encodes the protein NEDD1.
NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.
References
Further reading
- Pinyol R, Scrofani J, Vernos I. (2012). "The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function.". Curr Biol. 23 (2): 143–9. doi:10.1016/j.cub.2012.11.046. PMID 23273898.
- Sdelci S, Schütz M, Pinyol R, et al. (2012). "Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.". Curr Biol. 22 (16): 1516–23. doi:10.1016/j.cub.2012.06.027. PMID 22818914.
- Haren L, Remy MH, Bazin I, et al. (2006). "NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly.". J. Cell Biol. 172 (4): 505–15. doi:10.1083/jcb.200510028. PMC 2063671. PMID 16461362.
- Lüders J, Patel UK, Stearns T (2006). "GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.". Nat. Cell Biol. 8 (2): 137–47. doi:10.1038/ncb1349. PMID 16378099.
- Jung SY, Malovannaya A, Wei J, et al. (2005). "Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.". Mol. Endocrinol. 19 (10): 2451–65. doi:10.1210/me.2004-0476. PMID 16051665.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Takai S, Yoshida Y, Noda M, et al. (1995). "Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization.". Hum. Genet. 95 (1): 96–8. doi:10.1007/BF00225082. PMID 7814034.
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