NEIL3

Nei-like DNA glycosylase 3
Identifiers
Symbols	NEIL3 ; FGP2; FPG2; NEI3; ZGRF3; hFPG2; hNEI3
External IDs	OMIM: 608934 HomoloGene: 10094 GeneCards: NEIL3 Gene
EC number	4.2.99.18
Gene ontology Molecular function • bubble DNA binding • damaged DNA binding • double-stranded DNA binding • single-stranded DNA binding • DNA-(apurinic or apyrimidinic site) lyase activity • zinc ion binding • DNA N-glycosylase activity Cellular component • nucleus Biological process • base-excision repair • nucleotide-excision repair Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55247	234258
Ensembl	ENSG00000109674	ENSMUSG00000039396
UniProt	Q8TAT5	Q8K203
RefSeq (mRNA)	NM_018248	NM_146208
RefSeq (protein)	NP_060718	NP_666320
Location (UCSC)	Chr 4: 177.31 – 177.36 Mb	Chr 8: 53.59 – 53.64 Mb
PubMed search

Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene.^[1]

NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.^[2]

References

1. "Entrez Gene: Nei endonuclease VIII-like 3 (E. coli)".
2. Bandaru V, Sunkara S, Wallace SS, Bond JP (July 2002). "A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII". DNA Repair (Amst.) 1 (7): 517–29. doi:10.1016/S1568-7864(02)00036-8. PMID 12509226.