NEK1

NIMA-related kinase 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4APC​, 4B9D​
Identifiers
Symbols	NEK1 ; NY-REN-55; SRPS2; SRPS2A; SRTD6
External IDs	OMIM: 604588 MGI: 97303 HomoloGene: 14376 ChEMBL: 5855 GeneCards: NEK1 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein kinase activity • protein serine/threonine kinase activity • MAP kinase kinase activity • protein tyrosine kinase activity • protein binding • ATP binding • kinase activity • metal ion binding Cellular component • pericentriolar material • intracellular • nucleus • cytoplasm • centrosome Biological process • MAPK cascade • activation of MAPK activity • kidney development • protein phosphorylation • cellular response to DNA damage stimulus • mitotic nuclear division • spermatogenesis • response to ionizing radiation • peptidyl-tyrosine phosphorylation • multicellular organism growth • cilium assembly • cell division • regulation of DNA damage checkpoint Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4750	18004
Ensembl	ENSG00000137601	ENSMUSG00000031644
UniProt	Q96PY6	P51954
RefSeq (mRNA)	NM_001199397	NM_001293637
RefSeq (protein)	NP_001186326	NP_001280566
Location (UCSC)	Chr 4: 169.39 – 169.61 Mb	Chr 8: 60.99 – 61.13 Mb
PubMed search

NIMA (never in mitosis gene a)-related kinase 1, also known as NEK1, is a human gene highly expressed in germ cells and thought to be involved in meiosis. It is also involved in the response to DNA damage to radiation.^[1]

References

1. "Entrez Gene: NEK1 NIMA (never in mitosis gene a)-related kinase 1".

Further reading

• Letwin K, Mizzen L, Motro B, et al. (1992). "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.". EMBO J. 11 (10): 3521–31. PMC 556810. PMID 1382974.
• Upadhya P, Birkenmeir EH, Birkenmeir CS, et al. (2000). "Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice.". PNAS 97 (1): 217–221. doi:10.1073/pnas.97.1.217. PMC 26643. PMID 10618398.
• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". PNAS 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Surpili MJ, Delben TM, Kobarg J (2004). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1.". Biochemistry 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Polci R, Peng A, Chen PL, et al. (2005). "NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.". Cancer Res. 64 (24): 8800–3. doi:10.1158/0008-5472.CAN-04-2243. PMID 15604234.