NEO1

Neogenin 1
PDB rendering based on 1x5f.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1X5F​, 1X5G​, 1X5H​, 1X5I​, 1X5J​, 1X5K​, 3P4L​
Identifiers
Symbols	NEO1 ; IGDCC2; NGN; NTN1R2
External IDs	OMIM: 601907 MGI: 1097159 HomoloGene: 1870 GeneCards: NEO1 Gene
Gene ontology Molecular function • receptor activity • co-receptor binding • cadherin binding Cellular component • plasma membrane • integral component of plasma membrane • plasma membrane protein complex Biological process • regulation of transcription, DNA-templated • cell adhesion • axon guidance • myoblast fusion • positive regulation of BMP signaling pathway • muscle cell differentiation • negative regulation of protein secretion • positive regulation of muscle cell differentiation • iron ion homeostasis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4756	18007
Ensembl	ENSG00000067141	ENSMUSG00000032340
UniProt	Q92859	Q7TQG5
RefSeq (mRNA)	NM_001172623	NM_001042752
RefSeq (protein)	NP_001166094	NP_001036217
Location (UCSC)	Chr 15: 73.05 – 73.31 Mb	Chr 9: 58.87 – 59.04 Mb
PubMed search

Neogenin is a protein that in humans is encoded by the NEO1 gene.^[1][2]

Interactions

NEO1 has been shown to interact with PTK2.^[3]

References

1. Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene 14 (10): 1129–36. doi:10.1038/sj.onc.1200935. PMID 9121761.
2. "Entrez Gene: NEO1 neogenin homolog 1 (chicken)".
3. Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (Nov 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733.

Further reading

• Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ (1995). "Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer.". J. Cell Biol. 127 (6 Pt 2): 2009–20. doi:10.1083/jcb.127.6.2009. PMC 2120299. PMID 7806578.
• Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS, Culotti JG, Tessier-Lavigne M (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.". Cell 87 (2): 175–85. doi:10.1016/S0092-8674(00)81336-7. PMID 8861902.
• Vielmetter J, Chen XN, Miskevich F, Lane RP, Yamakawa K, Korenberg JR, Dreyer WJ (1997). "Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23.". Genomics 41 (3): 414–21. doi:10.1006/geno.1997.4688. PMID 9169140.
• Wang H, Copeland NG, Gilbert DJ, Jenkins NA, Tessier-Lavigne M (1999). "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors.". J. Neurosci. 19 (12): 4938–47. PMID 10366627.
• Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis.". Dev. Cell 4 (3): 371–82. doi:10.1016/S1534-5807(03)00054-6. PMID 12636918.
• Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells.". Oncogene 22 (27): 4243–56. doi:10.1038/sj.onc.1206437. PMID 12833147.
• Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chédotal A (2004). "RGM and its receptor neogenin regulate neuronal survival.". Nat. Cell Biol. 6 (8): 749–55. doi:10.1038/ncb1157. PMID 15258591.
• Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC (2005). "Focal adhesion kinase in netrin-1 signaling.". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733.
• Lee JE, Kim HJ, Bae JY, Kim SW, Park JS, Shin HJ, Han W, Kim SW, Kang KS, Noh DY (2006). "Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer.". BMC Cancer 5: 154. doi:10.1186/1471-2407-5-154. PMC 1322231. PMID 16324219.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.