NET1

Neuroepithelial cell transforming 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3EO2​, 4XH9​
Identifiers
Symbols	NET1 ; ARHGEF8; NET1A
External IDs	OMIM: 606450 MGI: 1927138 HomoloGene: 4283 GeneCards: NET1 Gene
Gene ontology Molecular function • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • GTP-Rho binding Cellular component • nucleus • cytosol • plasma membrane Biological process • regulation of cell growth • signal transduction • small GTPase mediated signal transduction • regulation of Rho protein signal transduction • positive regulation of apoptotic process • positive regulation of GTPase activity • neurotrophin TRK receptor signaling pathway • regulation of small GTPase mediated signal transduction • myoblast migration • cellular response to hydrogen peroxide • cellular response to ionizing radiation • apoptotic signaling pathway • positive regulation of substrate adhesion-dependent cell spreading Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10276	56349
Ensembl	ENSG00000173848	ENSMUSG00000021215
UniProt	Q7Z628	Q9Z206
RefSeq (mRNA)	NM_001047160	NM_001047159
RefSeq (protein)	NP_001040625	NP_001040624
Location (UCSC)	Chr 10: 5.41 – 5.46 Mb	Chr 13: 3.88 – 3.92 Mb
PubMed search

Neuroepithelial cell-transforming gene 1 protein is a protein that in humans is encoded by the NET1 gene.^[1][2]

References

1. Chan AM, Takai S, Yamada K, Miki T (Jul 1996). "Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning". Oncogene 12 (6): 1259–66. PMID 8649828.
2. "Entrez Gene: NET1 neuroepithelial cell transforming gene 1".

Further reading

• Shen X, Li J, Hu PP, et al. (2001). "The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation.". J. Biol. Chem. 276 (18): 15362–8. doi:10.1074/jbc.M009534200. PMID 11278519.
• Dobrosotskaya IY (2001). "Identification of mNET1 as a candidate ligand for the first PDZ domain of MAGI-1.". Biochem. Biophys. Res. Commun. 283 (4): 969–75. doi:10.1006/bbrc.2001.4880. PMID 11350080.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Qin H, Carr HS, Wu X, et al. (2005). "Characterization of the biochemical and transforming properties of the neuroepithelial transforming protein 1.". J. Biol. Chem. 280 (9): 7603–13. doi:10.1074/jbc.M412141200. PMID 15611121.
• Alberts AS, Qin H, Carr HS, Frost JA (2005). "PAK1 negatively regulates the activity of the Rho exchange factor NET1.". J. Biol. Chem. 280 (13): 12152–61. doi:10.1074/jbc.M405073200. PMID 15684429.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Leyden J, Murray D, Moss A, et al. (2006). "Net1 and Myeov: computationally identified mediators of gastric cancer.". Br. J. Cancer 94 (8): 1204–12. doi:10.1038/sj.bjc.6603054. PMC 2361249. PMID 16552434.
• García-Mata R, Dubash AD, Sharek L, et al. (2007). "The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity.". Mol. Cell. Biol. 27 (24): 8683–97. doi:10.1128/MCB.00157-07. PMC 2169424. PMID 17938206.

External links

• NET1 human gene location in the UCSC Genome Browser.
• NET1 human gene details in the UCSC Genome Browser.