NETO1
| Neuropilin (NRP) and tolloid (TLL)-like 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | NETO1 ; BCTL1; BTCL1 | ||||||||||||
| External IDs | OMIM: 607973 HomoloGene: 16367 GeneCards: NETO1 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 81832 | 246317 | |||||||||||
| Ensembl | ENSG00000166342 | ENSMUSG00000050321 | |||||||||||
| UniProt | Q8TDF5 | Q8R4I7 | |||||||||||
| RefSeq (mRNA) | NM_001201465 | NM_144946 | |||||||||||
| RefSeq (protein) | NP_001188394 | NP_659195 | |||||||||||
| Location (UCSC) |
Chr 18: 72.74 – 72.87 Mb |
Chr 18: 86.39 – 86.5 Mb | |||||||||||
| PubMed search | |||||||||||||
Neuropilin (NRP) and tolloid (TLL)-like 1 is a protein that in humans is encoded by the NETO1 gene. [1]
Function
This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
References
- ↑ "Entrez Gene: Neuropilin (NRP) and tolloid (TLL)-like 1". Retrieved 2014-05-14.
Further reading
- Ng, D; Pitcher, G. M.; Szilard, R. K.; Sertié, A; Kanisek, M; Clapcote, S. J.; Lipina, T; Kalia, L. V.; Joo, D; McKerlie, C; Cortez, M; Roder, J. C.; Salter, M. W.; McInnes, R. R. (2009). "Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning". PLoS Biology 7 (2): e41. doi:10.1371/journal.pbio.1000041. PMC 2652390. PMID 19243221.
- Banno, M; Koide, T; Aleksic, B; Yamada, K; Kikuchi, T; Kohmura, K; Adachi, Y; Kawano, N; Kushima, I; Ikeda, M; Inada, T; Yoshikawa, T; Iwata, N; Ozaki, N (2011). "A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population". PLoS ONE 6 (12): e28929. doi:10.1371/journal.pone.0028929. PMC 3243668. PMID 22205981.
- Stöhr, H; Berger, C; Fröhlich, S; Weber, B. H. (2002). "A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class a module: Isolation of alternatively spliced isoforms in retina and brain". Gene 286 (2): 223–31. doi:10.1016/s0378-1119(02)00438-9. PMID 11943477.
- Porcu, E; Medici, M; Pistis, G; Volpato, C. B.; Wilson, S. G.; Cappola, A. R.; Bos, S. D.; Deelen, J; Den Heijer, M; Freathy, R. M.; Lahti, J; Liu, C; Lopez, L. M.; Nolte, I. M.; O'Connell, J. R.; Tanaka, T; Trompet, S; Arnold, A; Bandinelli, S; Beekman, M; Böhringer, S; Brown, S. J.; Buckley, B. M.; Camaschella, C; De Craen, A. J.; Davies, G; De Visser, M. C.; Ford, I; Forsen, T; et al. (2013). "A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function". PLoS Genetics 9 (2): e1003266. doi:10.1371/journal.pgen.1003266. PMC 3567175. PMID 23408906.
- Benjamin, D. J.; Cesarini, D.; Van Der Loos, M. J. H. M.; Dawes, C. T.; Koellinger, P. D.; Magnusson, P. K. E.; Chabris, C. F.; Conley, D.; Laibson, D.; Johannesson, M.; Visscher, P. M. (2012). "The genetic architecture of economic and political preferences". Proceedings of the National Academy of Sciences 109 (21): 8026–8031. doi:10.1073/pnas.1120666109. PMC 3361436. PMID 22566634.
- O'Donnell, L; Soileau, B; Heard, P; Carter, E; Sebold, C; Gelfond, J; Hale, D. E.; Cody, J. D. (2010). "Genetic determinants of autism in individuals with deletions of 18q". Human Genetics 128 (2): 155–64. doi:10.1007/s00439-010-0839-y. PMID 20499253.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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