NF-kappa-B-activating protein

NFKB activating protein
Identifiers
Symbols	NKAP ; FLJ22626
External IDs	OMIM: 300766 MGI: 1914300 HomoloGene: 134325 GeneCards: NKAP Gene
Gene ontology Molecular function • chromatin binding • protein binding • chromatin DNA binding • poly(A) RNA binding Cellular component • nucleoplasm • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • Notch signaling pathway • stem cell maintenance • granulocyte differentiation • T cell differentiation in thymus • negative regulation of transcription, DNA-templated • positive regulation of alpha-beta T cell differentiation • hematopoietic stem cell proliferation • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79576	67050
Ensembl	ENSG00000101882	ENSMUSG00000016409
UniProt	Q8N5F7	Q9D0F4
RefSeq (mRNA)	NM_024528	NM_025937
RefSeq (protein)	NP_078804	NP_080213
Location (UCSC)	Chr X: 119.92 – 119.94 Mb	Chr X: 37.13 – 37.15 Mb
PubMed search

NF-kappa-B-activating protein is a protein that in humans is encoded by the NKAP gene.^[1][2]

References

1. Chen D, Li Z, Yang Q, Zhang J, Zhai Z, Shu HB (Oct 2003). "Identification of a nuclear protein that promotes NF-kappaB activation". Biochem Biophys Res Commun 310 (3): 720–4. doi:10.1016/j.bbrc.2003.09.074. PMID 14550261.
2. "Entrez Gene: NKAP NF-kappaB activating protein".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ghiorzo P, Mantelli M, Gargiulo S, et al. (2004). "Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progression". Hum. Pathol. 35 (8): 1029–37. doi:10.1016/j.humpath.2004.02.017. PMID 15297971.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Zhande R, Karsan A (2007). "Erythropoietin promotes survival of primary human endothelial cells through PI3K-dependent, NF-kappaB-independent upregulation of Bcl-xL". Am. J. Physiol. Heart Circ. Physiol. 292 (5): H2467–74. doi:10.1152/ajpheart.00649.2006. PMID 17237249.