NLGN1

Neuroligin 1
Identifiers
Symbols	NLGN1 ; NL1
External IDs	OMIM: 600568 MGI: 2179435 HomoloGene: 56690 GeneCards: NLGN1 Gene
Gene ontology Molecular function • cholinesterase activity • receptor activity • PDZ domain binding • neurexin family protein binding • protein dimerization activity • cell adhesion molecule binding • scaffold protein binding Cellular component • extracellular space • Golgi apparatus • plasma membrane • integral component of plasma membrane • external side of plasma membrane • cell surface • postsynaptic density • NMDA selective glutamate receptor complex • cell junction • dendrite • filopodium tip • dendritic spine • dendritic shaft • synapse • postsynaptic membrane • excitatory synapse • neuronal postsynaptic density Biological process • regulation of respiratory gaseous exchange by neurological system process • acetylcholine catabolic process • protein targeting • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • neuron cell-cell adhesion • nervous system development • synapse assembly • positive regulation of circadian sleep/wake cycle, wakefulness • synaptic vesicle targeting • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • neuronal signal transduction • neuron projection development • positive regulation of synaptic transmission, GABAergic • protein localization to synapse • establishment of protein localization • regulation of neuron differentiation • synaptic vesicle endocytosis • rhythmic process • cytoskeletal matrix organization at active zone • modulation of synaptic transmission • protein homooligomerization • protein heterotetramerization • positive regulation of filopodium assembly • positive regulation of synapse assembly • positive regulation of synaptic transmission, glutamatergic • long-term synaptic potentiation • positive regulation of dendritic spine development • negative regulation of dendritic spine morphogenesis • terminal button organization • synaptic vesicle clustering • postsynaptic membrane assembly • presynaptic membrane assembly • AMPA glutamate receptor clustering • NMDA glutamate receptor clustering • neurexin clustering involved in presynaptic membrane assembly • postsynaptic density protein 95 clustering • receptor localization to synapse • positive regulation of ruffle assembly • positive regulation of synaptic vesicle endocytosis • positive regulation of protein localization to synapse • positive regulation of intracellular signal transduction • positive regulation of synaptic vesicle exocytosis • regulation of N-methyl-D-aspartate selective glutamate receptor activity • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity • positive regulation of excitatory postsynaptic potential • positive regulation of synaptic vesicle clustering Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22871	192167
Ensembl	ENSG00000169760	ENSMUSG00000063887
UniProt	Q8N2Q7	Q99K10
RefSeq (mRNA)	NM_014932	NM_001163387
RefSeq (protein)	NP_055747	NP_001156859
Location (UCSC)	Chr 3: 173.4 – 174.29 Mb	Chr 3: 25.43 – 26.33 Mb
PubMed search

Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.^[1][2][3]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.^[3][4]

Interactions

NLGN1 has been shown to interact with NRXN1^[5][6] and DLG4.^[7]

See also

• Neurexins: NRXN1, NRXN2, NRXN3

References

1. Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (April 2000). "The structure and expression of the human neuroligin-3 gene". Gene 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
2. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
3. "Entrez Gene: NLGN1 neuroligin 1".
4. Scheiffele P, Fan J, Choih J, Fetter R, Serafini T (June 2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell 101 (6): 657–69. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652.
5. Comoletti D, Flynn R, Jennings LL, et al. (December 2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". The Journal of Biological Chemistry 278 (50): 50497–505. doi:10.1074/jbc.M306803200. PMID 14522992.
6. Ichtchenko K, Nguyen T, Südhof TC (February 1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". The Journal of Biological Chemistry 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240.
7. Irie M, Hata Y, Takeuchi M, et al. (September 1997). "Binding of neuroligins to PSD-95". Science 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515.

Further reading

• Cantallops I, Cline HT (September 2000). "Synapse formation: if it looks like a duck and quacks like a duck ..". Current Biology 10 (17): R620–3. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085.
• Ichtchenko K, Hata Y, Nguyen T, et al. (May 1995). "Neuroligin 1: a splice site-specific ligand for beta-neurexins". Cell 81 (3): 435–43. doi:10.1016/0092-8674(95)90396-8. PMID 7736595.
• Ichtchenko K, Nguyen T, Südhof TC (February 1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". The Journal of Biological Chemistry 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240.
• Irie M, Hata Y, Takeuchi M, et al. (September 1997). "Binding of neuroligins to PSD-95". Science 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515.
• Kikuno R, Nagase T, Ishikawa K, et al. (June 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Scheiffele P, Fan J, Choih J, Fetter R, Serafini T (June 2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell 101 (6): 657–69. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652.
• Strausberg RL, Feingold EA, Grouse LH, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Comoletti D, Flynn R, Jennings LL, et al. (December 2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". The Journal of Biological Chemistry 278 (50): 50497–505. doi:10.1074/jbc.M306803200. PMID 14522992.
• Ota T, Suzuki Y, Nishikawa T, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (October 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Research 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC (June 2005). "Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism". The Journal of Biological Chemistry 280 (23): 22365–74. doi:10.1074/jbc.M410723200. PMID 15797875.
• Muzny DM, Scherer SE, Kaul R, et al. (April 2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.
• Li X, Zhang J, Cao Z, Wu J, Shi Y (September 2006). "Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin". Protein Science 15 (9): 2149–58. doi:10.1110/ps.062087506. PMC 2242614. PMID 16882988.