NLGN2

Neuroligin 2
Identifiers
Symbols	NLGN2 ; KIAA1366
External IDs	OMIM: 606479 MGI: 2681835 HomoloGene: 69317 GeneCards: NLGN2 Gene
Gene ontology Molecular function • cholinesterase activity • receptor activity • neurexin family protein binding • cell adhesion molecule binding Cellular component • extracellular space • integral component of plasma membrane • cell surface • membrane • cell junction • presynaptic membrane • synapse • postsynaptic membrane • inhibitory synapse Biological process • regulation of respiratory gaseous exchange by neurological system process • acetylcholine catabolic process • neuron cell-cell adhesion • synapse assembly • single organismal cell-cell adhesion • sensory perception of pain • positive regulation of insulin secretion • positive regulation of synaptic transmission, GABAergic • protein localization to synapse • locomotory exploration behavior • cell-cell junction maintenance • synaptic vesicle endocytosis • modulation of synaptic transmission • synapse organization • neuromuscular process controlling balance • positive regulation of synapse assembly • positive regulation of synaptic transmission, glutamatergic • terminal button organization • postsynaptic membrane assembly • presynaptic membrane assembly • gephyrin clustering involved in postsynaptic density assembly • postsynaptic density protein 95 clustering • positive regulation of inhibitory postsynaptic potential • positive regulation of protein localization to synapse • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity • positive regulation of excitatory postsynaptic potential • positive regulation of synaptic vesicle clustering Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57555	216856
Ensembl	ENSG00000169992	ENSMUSG00000051790
UniProt	Q8NFZ4	Q69ZK9
RefSeq (mRNA)	NM_020795	NM_198862
RefSeq (protein)	NP_065846	NP_942562
Location (UCSC)	Chr 17: 7.4 – 7.42 Mb	Chr 11: 69.82 – 69.84 Mb
PubMed search

Neuroligin-2 is a protein that in humans is encoded by the NLGN2 gene.^[1][2][3]

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.^[3]

References

1. Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
2. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
3. "Entrez Gene: NLGN2 neuroligin 2".

Further reading

• Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ...". Curr. Biol. 10 (17): R620–3. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085.
• Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240.
• Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95". Science 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515.
• Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Scheiffele P, Fan J, Choih J, et al. (2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell 101 (6): 657–69. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMC 1925054. PMID 12669065.