NME3

NME/NM23 nucleoside diphosphate kinase 3
PDB rendering based on 1zs6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ZS6​
Identifiers
Symbols	NME3 ; DR-nm23; NDPK-C; NDPKC; NM23-H3; NM23H3; c371H6.2
External IDs	OMIM: 601817 MGI: 1930182 HomoloGene: 20562 ChEMBL: 4871 GeneCards: NME3 Gene
EC number	2.7.4.6
Gene ontology Molecular function • nucleoside diphosphate kinase activity • protein binding • ATP binding • metal ion binding Cellular component • intracellular • mitochondrion • cytosol • extracellular exosome Biological process • purine nucleotide metabolic process • nucleoside diphosphate phosphorylation • GTP biosynthetic process • pyrimidine nucleotide metabolic process • UTP biosynthetic process • CTP biosynthetic process • apoptotic process • nucleoside triphosphate biosynthetic process • regulation of apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4832	79059
Ensembl	ENSG00000103024	ENSMUSG00000073435
UniProt	Q13232	Q9WV85
RefSeq (mRNA)	NM_002513	NM_019730
RefSeq (protein)	NP_002504	NP_062704
Location (UCSC)	Chr 16: 1.77 – 1.77 Mb	Chr 17: 24.9 – 24.9 Mb
PubMed search

Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene.^[1][2]

Interactions

NME3 has been shown to interact with NME1^[3][4] and NME2.^[4][5]

References

1. Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B (April 1997). "Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family". Cancer Res. 57 (6): 1180–7. PMID 9067290.
2. "Entrez Gene: NME3 non-metastatic cells 3, protein expressed in".
3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
4. Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.
5. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Further reading

• Venturelli D, Martinez R, Melotti P, Casella I, Peschle C, Cucco C, Spampinato G, Darzynkiewicz Z, Calabretta B (1995). "Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7435–9. doi:10.1073/pnas.92.16.7435. PMC 41354. PMID 7638209.
• Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL (2006). "p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4717–22. doi:10.1073/pnas.0600585103. PMC 1450237. PMID 16537434.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Carinci F, Arcelli D, Lo Muzio L, Francioso F, Valentini D, Evangelisti R, Volinia S, D'Angelo A, Meroni G, Zollo M, Pastore A, Ionna F, Mastrangelo F, Conti P, Tetè S (2007). "Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma". Transl Res 150 (4): 233–45. doi:10.1016/j.trsl.2007.03.011. PMID 17900511.