NOVA1

Neuro-oncological ventral antigen 1
PDB rendering based on 1dt4.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1DT4​, 2ANN​, 2ANR​
Identifiers
Symbols	NOVA1 ; Nova-1
External IDs	OMIM: 602157 HomoloGene: 21296 GeneCards: NOVA1 Gene
Gene ontology Molecular function • RNA binding • mRNA binding • poly(A) RNA binding Cellular component • nucleus • nucleolus • intracellular membrane-bounded organelle Biological process • mRNA splicing, via spliceosome • RNA processing • synaptic transmission • locomotory behavior • RNA splicing • regulation of RNA metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4857	664883
Ensembl	ENSG00000139910	ENSMUSG00000021047
UniProt	P51513	Q9JKN6
RefSeq (mRNA)	NM_002515	NM_021361
RefSeq (protein)	NP_002506	NP_067336
Location (UCSC)	Chr 14: 26.44 – 26.6 Mb	Chr 12: 46.69 – 46.82 Mb
PubMed search

RNA-binding protein Nova-1 is a protein that in humans is encoded by the NOVA1 gene.^[1][2]

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.^[2]

References

1. Buckanovich RJ, Yang YY, Darnell RB (Feb 1996). "The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies". J Neurosci 16 (3): 1114–22. PMID 8558240.
2. "Entrez Gene: NOVA1 neuro-oncological ventral antigen 1".

Further reading

• Buckanovich RJ, Posner JB, Darnell RB (1993). "Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system". Neuron 11 (4): 657–72. doi:10.1016/0896-6273(93)90077-5. PMID 8398153.
• Buckanovich RJ, Darnell RB (1997). "The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo". Mol. Cell. Biol. 17 (6): 3194–201. PMC 232172. PMID 9154818.
• Lewis HA, Chen H, Edo C, et al. (1999). "Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains". Structure 7 (2): 191–203. doi:10.1016/S0969-2126(99)80025-2. PMID 10368286.
• Jensen KB, Dredge BK, Stefani G, et al. (2000). "Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability". Neuron 25 (2): 359–71. doi:10.1016/S0896-6273(00)80900-9. PMID 10719891.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dredge BK, Darnell RB (2003). "Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer". Mol. Cell. Biol. 23 (13): 4687–700. doi:10.1128/MCB.23.13.4687-4700.2003. PMC 164843. PMID 12808107.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ule J, Ule A, Spencer J, et al. (2005). "Nova regulates brain-specific splicing to shape the synapse". Nat. Genet. 37 (8): 844–52. doi:10.1038/ng1610. PMID 16041372.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.