NPAT (gene)

Nuclear protein, ataxia-telangiectasia locus
Identifiers
Symbols	NPAT ; E14; E14/NPAT; p220
External IDs	OMIM: 601448 MGI: 107605 HomoloGene: 1888 GeneCards: NPAT Gene
Gene ontology Molecular function • transcription coactivator activity • transcription corepressor activity • protein binding • protein C-terminus binding • protein N-terminus binding Cellular component • nucleus • nucleoplasm • cytoplasm • Cajal body • Gemini of coiled bodies Biological process • regulation of transcription involved in G1/S transition of mitotic cell cycle • transcription, DNA-templated • regulation of gene expression • positive regulation of transcription, DNA-templated • negative regulation of nucleic acid-templated transcription Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4863	244879
Ensembl	ENSG00000149308	ENSMUSG00000033054
UniProt	Q14207	Q8BMA5
RefSeq (mRNA)	NM_002519	NM_001081152
RefSeq (protein)	NP_002510	NP_001074621
Location (UCSC)	Chr 11: 108.16 – 108.22 Mb	Chr 9: 53.54 – 53.57 Mb
PubMed search

Protein NPAT also known as nuclear protein of the ATM locus is a protein that in humans is encoded by the NPAT gene.^[1][2]

Interactions

NPAT (gene) has been shown to interact with Glyceraldehyde 3-phosphate dehydrogenase^[3] and POU2F1.^[3]

References

1. Imai T, Sugawara T, Nishiyama A, Shimada R, Ohki R, Seki N, Sagara M, Ito H, Yamauchi M, Hori T (Jun 1997). "The structure and organization of the human NPAT gene". Genomics 42 (3): 388–92. doi:10.1006/geno.1997.4769. PMID 9205109.
2. "Entrez Gene: NPAT nuclear protein, ataxia-telangiectasia locus".
3. Zheng L, Roeder RG, Luo Y (Jul 2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component". Cell 114 (2): 255–66. doi:10.1016/S0092-8674(03)00552-X. PMID 12887926.

Further reading

• Imai T, Yamauchi M, Seki N, Sugawara T, Saito T, Matsuda Y, Ito H, Nagase T, Nomura N, Hori T (May 1996). "Identification and characterization of a new gene physically linked to the ATM gene". Genome Research 6 (5): 439–47. doi:10.1101/gr.6.5.439. PMID 8743993.
• Byrd PJ, McConville CM, Cooper P, Parkhill J, Stankovic T, McGuire GM, Thick JA, Taylor AM (Jan 1996). "Mutations revealed by sequencing the 5' half of the gene for ataxia telangiectasia". Human Molecular Genetics 5 (1): 145–9. doi:10.1093/hmg/5.1.145. PMID 8789452.
• Byrd PJ, Cooper PR, Stankovic T, Kullar HS, Watts GD, Robinson PJ, Taylor MR (Nov 1996). "A gene transcribed from the bidirectional ATM promoter coding for a serine rich protein: amino acid sequence, structure and expression studies". Human Molecular Genetics 5 (11): 1785–91. doi:10.1093/hmg/5.11.1785. PMID 8923007.
• Zhao J, Dynlacht B, Imai T, Hori T, Harlow E (Feb 1998). "Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry". Genes & Development 12 (4): 456–61. doi:10.1101/gad.12.4.456. PMC 316526. PMID 9472014.
• Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E (Sep 2000). "NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription". Genes & Development 14 (18): 2283–97. doi:10.1101/gad.827700. PMC 316937. PMID 10995386.
• Sagara M, Takeda E, Nishiyama A, Utsumi S, Toyama Y, Yuasa S, Ninomiya Y, Imai T (Dec 2002). "Characterization of functional regions for nuclear localization of NPAT". Journal of Biochemistry 132 (6): 875–9. doi:10.1093/oxfordjournals.jbchem.a003300. PMID 12473189.
• Gao G, Bracken AP, Burkard K, Pasini D, Classon M, Attwooll C, Sagara M, Imai T, Helin K, Zhao J (Apr 2003). "NPAT expression is regulated by E2F and is essential for cell cycle progression". Molecular and Cellular Biology 23 (8): 2821–33. doi:10.1128/MCB.23.8.2821-2833.2003. PMC 152552. PMID 12665581.
• Wei Y, Jin J, Harper JW (May 2003). "The cyclin E/Cdk2 substrate and Cajal body component p220(NPAT) activates histone transcription through a novel LisH-like domain". Molecular and Cellular Biology 23 (10): 3669–80. doi:10.1128/MCB.23.10.3669-3680.2003. PMC 164767. PMID 12724424.
• Zheng L, Roeder RG, Luo Y (Jul 2003). "S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component". Cell 114 (2): 255–66. doi:10.1016/S0092-8674(03)00552-X. PMID 12887926.
• Ye X, Wei Y, Nalepa G, Harper JW (Dec 2003). "The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells". Molecular and Cellular Biology 23 (23): 8586–600. doi:10.1128/MCB.23.23.8586-8600.2003. PMC 262656. PMID 14612403.
• Wang A, Ikura T, Eto K, Ota MS (Dec 2004). "Dynamic interaction of p220(NPAT) and CBP/p300 promotes S-phase entry". Biochemical and Biophysical Research Communications 325 (4): 1509–16. doi:10.1016/j.bbrc.2004.10.198. PMID 15555599.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Kalla C, Scheuermann MO, Kube I, Schlotter M, Mertens D, Döhner H, Stilgenbauer S, Lichter P (May 2007). "Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B". European Journal of Cancer 43 (8): 1328–35. doi:10.1016/j.ejca.2007.02.005. PMID 17449237.
• Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS (Nov 2007). "The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes". Cancer Research 67 (21): 10334–42. doi:10.1158/0008-5472.CAN-07-1560. PMID 17974976.