NPRL2

NPR2-like, GATOR1 complex subunit
Identifiers
Symbols	NPRL2 ; NPR2; NPR2L; TUSC4
External IDs	OMIM: 607072 MGI: 1914482 HomoloGene: 4771 GeneCards: NPRL2 Gene
Gene ontology Molecular function • protein kinase activity • GTPase activator activity • protein binding Cellular component • Iml1 complex Biological process • protein phosphorylation • negative regulation of TOR signaling • negative regulation of kinase activity • cellular response to amino acid starvation • positive regulation of GTPase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10641	56032
Ensembl	ENSG00000114388	ENSMUSG00000010057
UniProt	Q8WTW4	Q9WUE4
RefSeq (mRNA)	NM_006545	NM_018879
RefSeq (protein)	NP_006536	NP_061367
Location (UCSC)	Chr 3: 50.35 – 50.35 Mb	Chr 9: 107.54 – 107.55 Mb
PubMed search

Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.^[1][2]

References

1. Lerman MI, Minna JD (Nov 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research 60 (21): 6116–33. PMID 11085536.
2. "Entrez Gene: TUSC4 tumor suppressor candidate 4".

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Ueda K, Kawashima H, Ohtani S, Deng WG, Ravoori M, Bankson J, Gao B, Girard L, Minna JD, Roth JA, Kundra V, Ji L (Oct 2006). "The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells". Cancer Research 66 (19): 9682–90. doi:10.1158/0008-5472.CAN-06-1483. PMID 17018626.
• Li J, Wang F, Haraldson K, Protopopov A, Duh FM, Geil L, Kuzmin I, Minna JD, Stanbridge E, Braga E, Kashuba VI, Klein G, Lerman MI, Zabarovsky ER (Sep 2004). "Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C". Cancer Research 64 (18): 6438–43. doi:10.1158/0008-5472.CAN-03-3869. PMID 15374952.
• Ji L, Nishizaki M, Gao B, Burbee D, Kondo M, Kamibayashi C, Xu K, Yen N, Atkinson EN, Fang B, Lerman MI, Roth JA, Minna JD (May 2002). "Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo". Cancer Research 62 (9): 2715–20. PMC 3478680. PMID 11980673.