NPTN

Neuroplastin
Identifiers
Symbols	NPTN ; GP55; GP65; SDFR1; SDR1; np55; np65
External IDs	OMIM: 612820 HomoloGene: 7531 GeneCards: NPTN Gene
Gene ontology Molecular function • transmembrane receptor protein tyrosine kinase activity • type 1 fibroblast growth factor receptor binding • cell adhesion molecule binding Cellular component • cytosol • cell surface • integral component of membrane • presynaptic membrane Biological process • positive regulation of protein phosphorylation • homophilic cell adhesion via plasma membrane adhesion molecules • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cytosolic calcium ion concentration • positive regulation of neuron projection development • peptidyl-tyrosine phosphorylation • positive regulation of fibroblast growth factor receptor signaling pathway • positive regulation of long-term neuronal synaptic plasticity • long-term synaptic potentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27020	n/a
Ensembl	ENSG00000156642	n/a
UniProt	Q9Y639	n/a
RefSeq (mRNA)	NM_001161363	n/a
RefSeq (protein)	NP_001154835	n/a
Location (UCSC)	Chr 15: 73.56 – 73.63 Mb	n/a
PubMed search		n/a

Neuroplastin is a protein that in humans is encoded by the NPTN gene.^[1][2][3]

Neuroplastin is a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. The alpha and beta transcripts show differential localization within the brain.^[3]

In 2014, in a study led by Dr. Sylvane Desrivières, of King's College London's Institute of Psychiatry found that "teenagers who had a highly functioning NPTN gene performed better in intelligence tests"^[4][5][6]

References

1. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
2. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
3. "Entrez Gene: NPTN neuroplastin".
4. Is intelligence written in the genes?
5. Researchers Find Gene that Links Grey Matter with Intelligence
6. Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents

Further reading

• Langnaese K, Beesley PW, Gundelfinger ED (1997). "Synaptic membrane glycoproteins gp65 and gp55 are new members of the immunoglobulin superfamily.". J. Biol. Chem. 272 (2): 821–7. doi:10.1074/jbc.272.2.821. PMID 8995369.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Saito A, Fujikura-Ouchi Y, Kuramasu A, et al. (2007). "Association study of putative promoter polymorphisms in the neuroplastin gene and schizophrenia.". Neurosci. Lett. 411 (3): 168–73. doi:10.1016/j.neulet.2006.08.042. PMID 17123723.
• Bernstein HG, Smalla KH, Bogerts B, et al. (2007). "The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain.". Brain Res. 1134 (1): 107–12. doi:10.1016/j.brainres.2006.11.090. PMID 17196182.