NSL1

NSL1, MIS12 kinetochore complex component
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NSL1 ; C1orf48; DC8; MIS14
External IDs OMIM: 609174 MGI: 2685830 HomoloGene: 22898 GeneCards: NSL1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 25936 381318
Ensembl ENSG00000117697 ENSMUSG00000062510
UniProt Q96IY1 D3Z4S2
RefSeq (mRNA) NM_001042549 NM_198654
RefSeq (protein) NP_001036014 NP_941056
Location (UCSC) Chr 1:
212.73 – 212.79 Mb
Chr 1:
191.06 – 191.09 Mb
PubMed search

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.[1]

This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

Interactions

NSL1 has been shown to interact with MIS12[2] and DSN1.[2]

References

  1. 1 2 "Entrez Gene: NSL1 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)".
  2. 1 2 Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. (England) 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821.

Further reading


This article is issued from Wikipedia - version of the Tuesday, September 01, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.