NUDT5

Nudix (nucleoside diphosphate linked moiety X)-type motif 5
PDB rendering based on 2dsb.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DSB​, 2DSC​, 2DSD​, 3AC9​, 3ACA​, 3BM4​, 3L85​
Identifiers
Symbols	NUDT5 ; YSA1; YSA1H; YSAH1; hYSAH1
External IDs	OMIM: 609230 MGI: 1858232 HomoloGene: 5388 GeneCards: NUDT5 Gene
EC number	3.6.1.13, 3.6.1.58
Gene ontology Molecular function • magnesium ion binding • nucleoside-diphosphatase activity • ADP-sugar diphosphatase activity • snoRNA binding • ADP-ribose diphosphatase activity • m7G(5')pppN diphosphatase activity Cellular component • intracellular • nucleus • cytosol • extracellular exosome Biological process • nucleotide metabolic process • ribonucleoside diphosphate catabolic process • D-ribose catabolic process • nucleobase-containing small molecule catabolic process • small molecule metabolic process • nucleobase-containing small molecule metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11164	53893
Ensembl	ENSG00000165609	ENSMUSG00000025817
UniProt	Q9UKK9	Q9JKX6
RefSeq (mRNA)	NM_014142	NM_016918
RefSeq (protein)	NP_054861	NP_058614
Location (UCSC)	Chr 10: 12.17 – 12.2 Mb	Chr 2: 5.85 – 5.87 Mb
PubMed search

ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene.^[1][2]

Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999).[supplied by OMIM]^[2]

References

1. McLennan AG (Aug 1999). "The MutT motif family of nucleotide phosphohydrolases in man and human pathogens (review)". Int J Mol Med 4 (1): 79–89. doi:10.3892/ijmm.4.1.79. PMID 10373642.
2. "Entrez Gene: NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5".

Further reading

• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ishibashi T, Hayakawa H, Sekiguchi M (2004). "A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides". EMBO Rep. 4 (5): 479–83. doi:10.1038/sj.embor.embor838. PMC 1319193. PMID 12717453.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Yang H, Slupska MM, Wei YF, et al. (2000). "Cloning and characterization of a new member of the Nudix hydrolases from human and mouse". J. Biol. Chem. 275 (12): 8844–53. doi:10.1074/jbc.275.12.8844. PMID 10722730.
• Gasmi L, Cartwright JL, McLennan AG (2000). "Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif". Biochem. J. 344 Pt 2 (Pt 2): 331–7. doi:10.1042/0264-6021:3440331. PMC 1220648. PMID 10567213.