NXF2

Nuclear RNA export factor 2
Identifiers
Symbols	NXF2 ; CT39; TAPL-2; TCP11X2
External IDs	OMIM: 300315 MGI: 2159343 HomoloGene: 88604 GeneCards: NXF2 Gene
Gene ontology Molecular function • nucleotide binding • RNA binding • protein binding Cellular component • nucleus • cytoplasm • nuclear RNA export factor complex Biological process • mRNA export from nucleus • multicellular organismal development • RNA transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56001	83454
Ensembl	ENSG00000269405	ENSMUSG00000009941
UniProt	Q9GZY0	Q80SZ6
RefSeq (mRNA)	NM_001039910	NM_001289735
RefSeq (protein)	NP_071336	NP_001276664
Location (UCSC)	Chr X: 102.25 – 102.33 Mb	Chr X: 134.94 – 134.96 Mb
PubMed search

Nuclear RNA export factor 2 is a protein that in humans is encoded by the NXF2 gene.^[1][2][3]

Function

This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene.^[3]

Interactions

NXF2 has been shown to interact with NUP214.^[1]

References

1. Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (Dec 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Molecular and Cellular Biology 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553. PMID 11073998.
2. Wang PJ, McCarrey JR, Yang F, Page DC (Apr 2001). "An abundance of X-linked genes expressed in spermatogonia". Nature Genetics 27 (4): 422–426. doi:10.1038/86927. PMID 11279525.
3. "Entrez Gene: NXF2 nuclear RNA export factor 2".

Further reading

• Black BE, Lévesque L, Holaska JM, Wood TC, Paschal BM (Dec 1999). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Molecular and Cellular Biology 19 (12): 8616–24. PMC 84993. PMID 10567585.
• Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C, Izaurralde E, Marynen P, Froyen G (Sep 2001). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Current Biology 11 (18): 1381–1391. doi:10.1016/S0960-9822(01)00419-5. PMID 11566096.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.