Naphthylvinylpyridine

Naphthylvinylpyridine

Names
IUPAC name 4-[(E)-2-naphthalen-1-ylethenyl]pyridine
Identifiers
CAS Number	16375-56-7
Jmol interactive 3D	Image
PubChem	5475238
SMILES C1=CC=C2C(=C1)C=CC=C2/C=C/C3=CC=NC=C3
Properties
Chemical formula	C17H13N
Molar mass	231.29 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Naphthylvinylpyridine (NVP) is a naphthalene derivative that possesses anticholinergic activity similar to that of atropine. However, NVP's method of acetylcholine (ACh) antagonism involves inhibiting the enzyme choline acetyltransferase.^[1]

Several NVP derivatives have been synthesized and evaluated for their ability to inhibit choline acetyltransferase and protect against nerve toxins.^[2][3]

References

1. Haubrich, DR; Goldberg, ME (1975). "Homovanillic acid concentration in the rat brain: Effect of a choline acetyltransferase inhibitor and comparison with cholinergic and dopaminergic agents". Neuropharmacology (Squibb Institute for Medical Research) 14 (3): 211–214. doi:10.1016/0028-3908(75)90007-6. PMID 1134625. Retrieved July 2011.
2. Cozzari, Costantino; Hartman, BK (1983). "Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase". Analytical Biochemistry (Department of Psychiatry and Neurobiology, Washington University School of Medicine) 133 (1): 120–125. doi:10.1016/0003-2697(83)90231-2. Retrieved July 2011.
3. Gray, AP; Henderson, TR (1988). "Approaches to protection against nerve agent poisoning". J Med Chem (Dynamac Corporation) 31 (4): 807–814. doi:10.1021/jm00399a022. PMID 3351860.