Nasal embryonic LHRH factor

NMDA receptor synaptonuclear signaling and neuronal migration factor
Identifiers
Symbols	NSMF ; HH9; NELF
External IDs	OMIM: 608137 MGI: 1861755 HomoloGene: 10648 GeneCards: NSMF Gene
Gene ontology Molecular function • calcium-dependent protein binding Cellular component • nucleus • nuclear envelope • nucleoplasm • nuclear euchromatin • cytoplasm • postsynaptic density • membrane • nuclear matrix • cell junction • dendrite • cortical cytoskeleton • nuclear membrane • neuron projection • perikaryon • synapse • postsynaptic membrane • apical dendrite Biological process • positive regulation of protein dephosphorylation • regulation of neuron apoptotic process • regulation of neuronal synaptic plasticity • regulation of dendrite morphogenesis • cellular response to amino acid stimulus • cellular response to electrical stimulus • cellular response to gonadotropin stimulus • positive regulation of neuron migration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26012	56876
Ensembl	ENSG00000165802	ENSMUSG00000006476
UniProt	Q6X4W1	Q99NF2
RefSeq (mRNA)	NM_001130969	NM_001039386
RefSeq (protein)	NP_001124441	NP_001034475
Location (UCSC)	Chr 9: 137.45 – 137.46 Mb	Chr 2: 25.05 – 25.06 Mb
PubMed search

Nasal embryonic luteinizing hormone-releasing hormone factor is a protein that in humans is encoded by the NELF gene.^[1][2][3]

References

1. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
2. Kramer PR, Wray S (Jul 2000). "Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons". Genes & Development 14 (14): 1824–34. doi:10.1101/gad.14.14.1824. PMC 316793. PMID 10898796.
3. "Entrez Gene: NELF nasal embryonic LHRH factor".

Further reading

• Miura K, Acierno JS, Seminara SB (2004). "Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH)". Journal of Human Genetics 49 (5): 265–8. doi:10.1007/s10038-004-0137-4. PMID 15362570.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.