Neomycin C transaminase

Neomycin C transaminase (EC 2.6.1.95, neoN (gene)) is an enzyme with systematic name 2-oxoglutarate:neomycin C aminotransferase.^[1]^[2] This enzyme catalyses the following chemical reaction

neomycin C + 2-oxoglutarate

\rightleftharpoons

6'''-deamino-6-oxoneomycin C + L-glutamate

The reaction occurs in vivo in the opposite direction.

References

↑ Huang, F., Spiteller, D., Koorbanally, N.A., Li, Y., Llewellyn, N.M. and Spencer, J.B. (2007). "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8: 283–288. doi:10.1002/cbic.200600371. PMID 17206729.
↑ Clausnitzer, D., Piepersberg, W. and Wehmeier, U.F. (2011). "The oxidoreductases LivQ and NeoQ are responsible for the different 6′-modifications in the aminoglycosides lividomycin and neomycin". J. Appl. Microbiol. 111: 642–651. doi:10.1111/j.1365-2672.2011.05082.x. PMID 21689223.

External links

Neomycin C transaminase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: nitrogenous groups (EC 2.6)

2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Ornithine aminotransferase Branched chain aminotransferase Alanine—glyoxylate transaminase AGXT

2.6.3: Oximinotransferases	Oximinotransferase

2.6.99: Other	Pyridoxine 5'-phosphate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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