Neridronic acid

Neridronic acid
Systematic (IUPAC) name

(6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid)
Identifiers
CAS Number	79778-41-9^Y
ATC code	none
PubChem	CID 71237
ChemSpider	64372^N
UNII	8U27U3RIN4^N
Chemical data
Formula	C₆H₁₇NO₇P₂
Molar mass	277.14 g/mol
SMILES C(CCC(O)(P(=O)(O)O)P(=O)(O)O)CCN
InChI InChI=1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)^N Key:PUUSSSIBPPTKTP-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Neridronic acid (INN; the anion is called neridronate) is a bisphosphonate. In Italy it is used to treat Osteogenesis imperfecta and Paget's disease of bone.^[1]

A 2013 clinical trial suggests CRPS Type I (Complex regional pain syndrome) responds to treatment with intravenous neridronate.^[2]

References

↑ NIH
↑ Varenna M, Adami S, Rossini M, et al. (March 2013). "Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study". Rheumatology 52 (3): 534–42. doi:10.1093/rheumatology/kes312. PMID 23204550.

Drugs for treatment of bone diseases (M05)

Bisphosphonates	Nitrogenous (Alendronic acid ibandronic acid incadronic acid pamidronic acid risedronic acid zoledronic acid) Non-nitrogenous (Etidronic acid clodronic acid tiludronic acid)

Bone morphogenetic proteins	Dibotermin alfa Eptotermin alfa

Other	Resorption inhibitor (Ipriflavone) Aluminium chlorohydrate Dual action bone agent (Strontium ranelate) RANKL inhibitor (Denosumab) Cathepsin K inhibitor (Odanacatib) Calcium Vitamin D

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