NTN1

Netrin 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4URT​
Identifiers
Symbols	NTN1 ; NTN1L
External IDs	OMIM: 601614 MGI: 105088 HomoloGene: 21008 ChEMBL: 1741307 GeneCards: NTN1 Gene
Gene ontology Molecular function • protein binding Cellular component • extracellular region • basement membrane • cytoplasm Biological process • neuron migration • apoptotic process • substrate-dependent cell migration, cell extension • Ras protein signal transduction • axon guidance • positive regulation of cell proliferation • single organismal cell-cell adhesion • regulation of cell migration • negative regulation of axon extension • Cdc42 protein signal transduction • anterior/posterior axon guidance • establishment of nucleus localization • inner ear morphogenesis • positive regulation of axon extension • mammary gland duct morphogenesis • positive regulation of cell motility Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9423	18208
Ensembl	ENSG00000065320	ENSMUSG00000020902
UniProt	O95631	O09118
RefSeq (mRNA)	NM_004822	NM_008744
RefSeq (protein)	NP_004813	NP_032770
Location (UCSC)	Chr 17: 9.02 – 9.24 Mb	Chr 11: 68.21 – 68.4 Mb
PubMed search

Netrin-1 is a protein that in humans is encoded by the NTN1 gene.^[1][2]

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.^[2]

Interactions

NTN1 has been shown to interact with Deleted in Colorectal Cancer.^[1][3]

References

1. Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER (Apr 1999). "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ 10 (1): 35–42. PMID 9950216.
2. "Entrez Gene: NTN1 netrin 1".
3. Geisbrecht, Brian V; Dowd Kimberly A; Barfield Ronald W; Longo Patti A; Leahy Daniel J (Aug 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. (United States) 278 (35): 32561–8. doi:10.1074/jbc.M302943200. ISSN 0021-9258. PMID 12810718.

Further reading

• Jalaleddinne Omar Bouhidel1, Ping Wang1, Kin Lung Siu, Hong Li, Ji Youn Youn, Hua Cai (2014). "Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy.". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852: 277–89. doi:10.1016/j.bbadis.2014.06.005. PMID 24928309.
• Arakawa H (2005). "Netrin-1 and its receptors in tumorigenesis.". Nat. Rev. Cancer 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119.
• Mehlen P, Furne C (2006). "Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis.". Cell. Mol. Life Sci. 62 (22): 2599–616. doi:10.1007/s00018-005-5191-3. PMID 16158190.
• Keino-Masu K, Masu M, Hinck L, et al. (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.". Cell 87 (2): 175–85. doi:10.1016/S0092-8674(00)81336-7. PMID 8861902.
• Serafini T, Colamarino SA, Leonardo ED, et al. (1997). "Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.". Cell 87 (6): 1001–14. doi:10.1016/S0092-8674(00)81795-X. PMID 8978605.
• Togari A, Mogi M, Arai M, et al. (2001). "Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts.". Brain Res. 878 (1–2): 204–9. doi:10.1016/S0006-8993(00)02700-1. PMID 10996153.
• Corset V, Nguyen-Ba-Charvet KT, Forcet C, et al. (2000). "Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor". Nature 407 (6805): 747–50. doi:10.1038/35037600. PMID 11048721.
• Manitt C, Colicos MA, Thompson KM, et al. (2001). "Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord". J. Neurosci. 21 (11): 3911–22. PMID 11356879.
• Srinivasan K, Strickland P, Valdes A, et al. (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis". Dev. Cell 4 (3): 371–82. doi:10.1016/S1534-5807(03)00054-6. PMID 12636918.
• Geisbrecht BV, Dowd KA, Barfield RW, et al. (2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
• Yebra M, Montgomery AM, Diaferia GR, et al. (2003). "Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration". Dev. Cell 5 (5): 695–707. doi:10.1016/S1534-5807(03)00330-7. PMID 14602071.
• Mazelin L, Bernet A, Bonod-Bidaud C, et al. (2004). "Netrin-1 controls colorectal tumorigenesis by regulating apoptosis". Nature 431 (7004): 80–4. doi:10.1038/nature02788. PMID 15343335.
• Kato HD, Kondoh H, Inoue T, et al. (2004). "Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis". Gynecol. Oncol. 95 (2): 281–9. doi:10.1016/j.ygyno.2004.07.050. PMID 15491747.
• Kruger RP, Lee J, Li W, Guan KL (2005). "Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation". J. Neurosci. 24 (48): 10826–34. doi:10.1523/JNEUROSCI.3715-04.2004. PMID 15574733.
• Hérincs Z, Corset V, Cahuzac N, et al. (2005). "DCC association with lipid rafts is required for netrin-1-mediated axon guidance". J. Cell. Sci. 118 (Pt 8): 1687–92. doi:10.1242/jcs.02296. PMID 15811950.
• Kim TH, Lee HK, Seo IA, et al. (2005). "Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron". J. Neurochem. 95 (1): 1–8. doi:10.1111/j.1471-4159.2005.03314.x. PMC 2683579. PMID 16181408.
• Ly NP, Komatsuzaki K, Fraser IP, et al. (2006). "Netrin-1 inhibits leukocyte migration in vitro and in vivo". Proc. Natl. Acad. Sci. U.S.A. 102 (41): 14729–34. doi:10.1073/pnas.0506233102. PMC 1253572. PMID 16203981.

External links

• NTN1 human gene location in the UCSC Genome Browser.
• NTN1 human gene details in the UCSC Genome Browser.