Neurogenin-1

Neurogenin 1
Identifiers
Symbols	NEUROG1 ; AKA; Math4C; NEUROD3; bHLHa6; ngn1
External IDs	OMIM: 601726 MGI: 107754 HomoloGene: 4490 GeneCards: NEUROG1 Gene
Gene ontology Molecular function • transcription factor activity, transcription factor binding • DNA binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • protein binding • protein dimerization activity • E-box binding Cellular component • nucleus • perikaryon Biological process • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • nervous system development • neuron differentiation • positive regulation of exit from mitosis • inner ear morphogenesis • cell fate commitment • positive regulation of neuron differentiation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4762	18014
Ensembl	ENSG00000181965	ENSMUSG00000048904
UniProt	Q92886	P70660
RefSeq (mRNA)	NM_006161	NM_010896
RefSeq (protein)	NP_006152	NP_035026
Location (UCSC)	Chr 5: 135.53 – 135.54 Mb	Chr 13: 56.25 – 56.25 Mb
PubMed search

Neurogenin-1 is a protein that in humans is encoded by the NEUROG1 gene.^[1][2]

Interactions

NEUROG1 has been shown to interact with CREB-binding protein^[3] and decapentaplegic homolog 1.^[3]

References

1. Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.
2. "Entrez Gene: NEUROG1 neurogenin 1".
3. Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME (Feb 2001). "Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms". Cell 104 (3): 365–76. doi:10.1016/S0092-8674(01)00224-0. PMID 11239394.

Further reading

• McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ (Oct 1996). "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family". Molecular and Cellular Biology 16 (10): 5792–800. doi:10.1128/mcb.16.10.5792. PMC 231580. PMID 8816493.
• Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME (Feb 2001). "Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms". Cell 104 (3): 365–76. doi:10.1016/S0092-8674(01)00224-0. PMID 11239394.
• Franklin A, Kao A, Tapscott S, Unis A (Nov 2001). "NeuroD homologue expression during cortical development in the human brain". Journal of Child Neurology 16 (11): 849–53. doi:10.1177/08830738010160111201. PMID 11732772.
• Kim S, Ghil SH, Kim SS, Myeong HH, Lee YD, Suh-Kim H (Dec 2002). "Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells". Experimental & Molecular Medicine 34 (6): 469–75. doi:10.1038/emm.2002.65. PMID 12526089.
• Fanous AH, Chen X, Wang X, Amdur RL, O'Neill FA, Walsh D, Kendler KS (Mar 2007). "Association between the 5q31.1 gene neurogenin1 and schizophrenia". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144B (2): 207–14. doi:10.1002/ajmg.b.30423. PMID 17044100.
• Liscovitch N, Chechik G (2013). "Specialization of gene expression during mouse brain development". PLoS Computational Biology 9 (9): e1003185. doi:10.1371/journal.pcbi.1003185. PMID 24068900.