Neuroimaging Informatics Tools and Resources Clearinghouse
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Web-based neuroimaging informatics tools and resources: collaborate, test, and compute | |
| Web address |
www |
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Type of site | Collaborative, Software Development Management System, Data Sets, Computational Environment |
| Users | Over 300,000 |
| Neuroimaging, Neuroinformatics | |
The Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) is a neuroimaging informatics knowledge environment for MR, PET/SPECT, CT, EEG/MEG, optical imaging, clinical neuroinformatics, imaging genomics, and computational neuroscience tools and resources.
Description
Initiated in 2006 and funded by the NIH Blueprint for Neuroscience Research, NIBIB, NIDA, NIMH, and NINDS,[1][2] NITRC’s mission is to provide a user-friendly knowledge environment that enables the distribution, enhancement, and adoption of neuroimaging tools and resources and has expanded from MR to Imaging Genomics, EEG/MEG, PET/SPECT, CT, optical imaging, clinical neuroinformatics, and computational neuroscience. Supporting 80,000+ page views per month, NITRC’s 535+ tools and resources have been downloaded 500,000+ times by a base of 235,000+ unique visitors.
NITRC’s goal is to support researchers dedicated to enhancing, adopting, distributing, and contributing to the evolution of previously funded neuroimaging analysis tools and resources for broader community use. Promoting software tools, workflows, resources, vocabularies, test data, and pre-processed, community-generated images through its Image Repository (NITRC-IR), NITRC gives researchers greater and more efficient access to the tools and resources they need; better categorizing and organizing existing tools and resources via a controlled vocabulary; facilitating interactions between researchers and developers through forums, direct email contact, ratings and reviews; and promoting better use through enhanced documentation.
Approach
To meet the disparate needs of neuroimaging informatics developers and researchers, NITRC offers collaborative functionality like that found in platforms such as GitHub and SourceForge. To provide such functionality, we customized the open-source GForge project. Thus, within NITRC, each tool or resource has the option to offer descriptive content as well as use MediaWiki, CVS/SVN, bug tracking, news, and forums to distribute information and downloads. Housed on NITRC servers and linked out to existing Web sites, NITRC is the source for neuroimaging informatics tools and resources.
Launched in 2007 with an agile programming schedule, the NITRC team continues to prioritize and implement functional and design enhancements to make the Web site even more accessible. While the scientific scope expands so do NITRC’s Enhanced Services, which include its Image Repository to support image data sharing and its Computational Environment service on Amazon Marketplace to support the execution of complex computational analysis of image data.
Services
The Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) suite of services include:
NITRC Resource Repository (NITRC-R) is the “go to” collaboration environment that enables the worldwide distribution, enhancement, and adoption of neuroinformatics tools and resources. NITRC-R’s scientific scope includes MR, PET/SPECT, CT, EEG/MEG, optical imaging, clinical neuroinformatics, imaging genomics, and most recently, computational neuroscience.
NITRC Image Repository (NITRC-IR), built on XNAT, is a curated repository of DICOM and NIfTI scanned images searchable by metadata such as diagnosis, handedness, gender, or group. NITRC-IR datasets include: 1000 Functional Connectomes, Autism Brain Imaging Data Exchange (ABIDE), INDI NKI/Rockland Sample, ADHD-200, Beijing Eyes Open Eyes Shut
NITRC Computational Environment (NITRC-CE) is a virtual big data compute service pre-configured with popular neuroimaging software analysis tools allowing pay-as-you-go compute time. Using AWS EC2, and leveraging NeuroDebian, NITRC-CE[3] and NITRC-CE for Cluster Compute Instances[4] are available via the AWS Marketplace. A public Amazon Machine Instance (AMI) is also available.
Results
NITRC’s triad of services serve the global neuroinformatics research community with 64% of its users coming from the United States, China, Germany, United Kingdom, and Canada. With over 3.2 million page views and 747,000 visits by 335,200 unique visitors, NITRC-R facilitates access to an ever growing number of neuroinformatics tools and resources (630). NITRC-IR offers 4,800 Subjects searchable across 9 projects to promote re-use and integration of these valuable shared data. Averaging 20,900 visits and 76,200 pageviews per month, software and data from NITRC-R and NITRC-IR have been downloaded over 1.3 million times. NITRC-CE provides simplified deployment of cloud-based computation that supports FreeSurfer, FSL, AFNI, and many other software resources. In real-world processing tests, a representative computation that would have taken 24 hours on a high-powered desktop took 25% of the time (8 hours) at a cost of only $4. The test was a FSL voxel-based morphometry (VBM) computation on 64 subjects from CANDIShare run on a 2.8 GHz Intel Xeon Mac desktop versus AWS Large instance (m1.large) using SGE parallelization over 4 cores.
Participants
NITRC is led by TCG of Washington, DC in collaboration with David N. Kennedy Consulting, Neuromorphometrics, and the Center for Research in Biological Systems of UCSD.