Neuropilin 2

Neuropilin 2
Rendering based on PDB 2QQJ​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2QQJ​, 2QQK​, 2QQL​, 2QQO​, 4QDQ​, 4QDR​, 4QDS​
Identifiers
Symbols	NRP2 ; NP2; NPN2; PRO2714; VEGF165R2
External IDs	OMIM: 602070 MGI: 1100492 HomoloGene: 2875 GeneCards: NRP2 Gene
Gene ontology Molecular function • receptor activity • vascular endothelial growth factor-activated receptor activity • heparin binding • semaphorin receptor activity • growth factor binding • cytokine binding • metal ion binding Cellular component • semaphorin receptor complex • extracellular region • plasma membrane • membrane • integral component of membrane Biological process • angiogenesis • positive regulation of endothelial cell proliferation • cell adhesion • axon guidance • positive regulation of endothelial cell migration • nerve development • vascular endothelial growth factor signaling pathway • vascular endothelial growth factor receptor signaling pathway • axon extension involved in axon guidance • sympathetic ganglion development • sympathetic neuron projection extension • sympathetic neuron projection guidance • semaphorin-plexin signaling pathway involved in neuron projection guidance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8828	18187
Ensembl	ENSG00000118257	ENSMUSG00000025969
UniProt	O60462	O35375
RefSeq (mRNA)	NM_003872	NM_001077403
RefSeq (protein)	NP_003863	NP_001070871
Location (UCSC)	Chr 2: 205.68 – 205.8 Mb	Chr 1: 62.7 – 62.82 Mb
PubMed search

Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene.^[1][2]

This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.^[3]

References

1. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (Apr 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell 92 (6): 735–45. doi:10.1016/S0092-8674(00)81402-6. PMID 9529250.
2. Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M (Nov 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348.
3. "Entrez Gene: NRP2 neuropilin 2".

Further reading

• Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (1999). "Vascular endothelial growth factor (VEGF) and its receptors.". FASEB J. 13 (1): 9–22. PMID 9872925.
• Kolodkin AL, Levengood DV, Rowe EG, et al. (1997). "Neuropilin is a semaphorin III receptor.". Cell 90 (4): 753–62. doi:10.1016/S0092-8674(00)80535-8. PMID 9288754.
• Giger RJ, Urquhart ER, Gillespie SK, et al. (1999). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.". Neuron 21 (5): 1079–92. doi:10.1016/S0896-6273(00)80625-X. PMID 9856463.
• Chen H, He Z, Bagri A, Tessier-Lavigne M (1999). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins.". Neuron 21 (6): 1283–90. doi:10.1016/S0896-6273(00)80648-0. PMID 9883722.
• Takahashi T, Nakamura F, Jin Z, et al. (1999). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors.". Nat. Neurosci. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.
• Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively.". Genomics 57 (3): 459–60. doi:10.1006/geno.1999.5790. PMID 10329017.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
• Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected].". J. Biol. Chem. 275 (24): 18040–5. doi:10.1074/jbc.M909259199. PMID 10748121.
• Handa A, Tokunaga T, Tsuchida T, et al. (2000). "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.". Int. J. Oncol. 17 (2): 291–5. doi:10.3892/ijo.17.2.291. PMID 10891538.
• Rossignol M, Gagnon ML, Klagsbrun M (2001). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms.". Genomics 70 (2): 211–22. doi:10.1006/geno.2000.6381. PMID 11112349.
• Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes.". J. Biol. Chem. 276 (22): 18688–94. doi:10.1074/jbc.M006909200. PMID 11278319.
• Cohen T, Gluzman-Poltorak Z, Brodzky A, et al. (2001). "Neuroendocrine cells along the digestive tract express neuropilin-2.". Biochem. Biophys. Res. Commun. 284 (2): 395–403. doi:10.1006/bbrc.2001.4958. PMID 11394892.
• Herzog Y, Kalcheim C, Kahane N, et al. (2002). "Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins.". Mech. Dev. 109 (1): 115–9. doi:10.1016/S0925-4773(01)00518-4. PMID 11677062.
• Oh H, Takagi H, Otani A, et al. (2002). "Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 383–8. doi:10.1073/pnas.012074399. PMC 117569. PMID 11756651.
• Fakhari M, Pullirsch D, Abraham D, et al. (2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma.". Cancer 94 (1): 258–63. doi:10.1002/cncr.10177. PMID 11815985.
• Cohen T, Herzog Y, Brodzky A, et al. (2002). "Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours.". J. Pathol. 198 (1): 77–82. doi:10.1002/path.1179. PMID 12210066.
• Kawakami T, Tokunaga T, Hatanaka H, et al. (2003). "Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma.". Cancer 95 (10): 2196–201. doi:10.1002/cncr.10936. PMID 12412174.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.