Neuroprotectin

Neuroprotectin D1 (NPD1) also known as Protectin D1 (PD1) is a docosanoid derived from the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), which is a component of fish oil and the most important omega-3 PUFA. NPD1 exerts potent[1] anti-inflammatory and anti-apoptotic/neuroprotective bioactivity.[2]

Neuroprotectins A and B are bicyclohexapeptides.[3]

References

  1. ↑ Hong S, Gronert K, Devchand PR, Moussignac RL, Serhan CN (2003). "Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation". J. Biol. Chem. 278 (17): 14677–87. doi:10.1074/jbc.M300218200. PMID 12590139.
  2. ↑ Bazan NG (2007). "Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection". Current opinion in clinical nutrition and metabolic care 10 (2): 136–41. doi:10.1097/MCO.0b013e32802b7030. PMID 17285000.
  3. ↑ Kobayashi H, Shin-Ya K, Nagai K, et al. (2001). "Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neuronal cells from excitotoxicity. I. Fermentation, isolation, physico-chemical properties and biological activity". J. Antibiot. 54 (12): 1013–8. doi:10.7164/antibiotics.54.1013. PMID 11858654.


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