Non-specific polyamine oxidase

Non-specific polyamine oxidase
Identifiers
EC number	1.5.3.17
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Non-specific polyamine oxidase (EC 1.5.3.17, polyamine oxidase, Fms1, AtPAO3) is an enzyme with systematic name polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming).^[1][2][3] This enzyme catalyses the following chemical reaction

(1) spermine + O₂ + H₂O $\rightleftharpoons$ spermidine + 3-aminopropanal + H₂O₂

(2) spermidine + O₂ + H₂O $\rightleftharpoons$ putrescine + 3-aminopropanal + H₂O₂

(3) N¹-acetylspermine + O₂ + H₂O $\rightleftharpoons$ spermidine + 3-acetamidopropanal + H₂O₂

(4) N¹-acetylspermidine + O₂ + H₂O $\rightleftharpoons$ putrescine + 3-acetamidopropanal + H₂O₂

This enzyme is flavoprotein (FAD).

References

1. Moschou, P.N., Sanmartin, M., Andriopoulou, A.H., Rojo, E., Sanchez-Serrano, J.J. and Roubelakis-Angelakis, K.A. (2008). "Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis". Plant Physiol. 147 (4): 1845–1857. doi:10.1104/pp.108.123802. PMC 2492618. PMID 18583528.
2. Muller, S. and Walter, R.D. (1992). "Purification and characterization of polyamine oxidase from Ascaris suum". Biochem. J. 283: 75–80. PMC 1130995. PMID 1567380.
3. Landry, J. and Sternglanz, R. (2003). "Yeast Fms1 is a FAD-utilizing polyamine oxidase". Biochem. Biophys. Res. Commun. 303 (3): 771–776. doi:10.1016/s0006-291x(03)00416-9. PMID 12670477.

External links

• Non-specific polyamine oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)