NUCB2
| Nucleobindin 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | NUCB2 ; HEL-S-109; NEFA | ||||||||||
| External IDs | OMIM: 608020 MGI: 1858179 HomoloGene: 3676 GeneCards: NUCB2 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 4925 | 53322 | |||||||||
| Ensembl | ENSG00000070081 | ENSMUSG00000030659 | |||||||||
| UniProt | P80303 | P81117 | |||||||||
| RefSeq (mRNA) | NM_005013 | NM_001130479 | |||||||||
| RefSeq (protein) | NP_005004 | NP_001123951 | |||||||||
| Location (UCSC) |
Chr 11: 17.21 – 17.35 Mb |
Chr 7: 116.5 – 116.54 Mb | |||||||||
| PubMed search | |||||||||||
Nucleobindin-2 is a protein that in humans is encoded by the NUCB2 gene.[1][2]
Nucleobindin-2 is a calcium-binding EF-hand protein.[supplied by OMIM][2]
Interactions
NUCB2 has been shown to interact with NDN.[3]
References
- ↑ Barnikol-Watanabe S, Gross NA, Gotz H, Henkel T, Karabinos A, Kratzin H, Barnikol HU, Hilschmann N (February 1995). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein". Biol Chem Hoppe Seyler 375 (8): 497–512. doi:10.1515/bchm3.1994.375.8.497. PMID 7811391.
- 1 2 "Entrez Gene: NUCB2 nucleobindin 2".
- ↑ Taniguchi, N; Taniura H; Niinobe M; Takayama C; Tominaga-Yoshino K; Ogura A; Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. (UNITED STATES) 275 (41): 31674–81. doi:10.1074/jbc.M005103200. ISSN 0021-9258. PMID 10915798.
Further reading
- DeAngelis MM, Doucet JP, Drury S, et al. (1998). "Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene". Biochim. Biophys. Acta 1407 (1): 84–91. doi:10.1016/s0925-4439(98)00025-8. PMID 9639681.
- Kroll KA, Otte S, Hirschfeld G, et al. (1999). "Heterologous overexpression of human NEFA and studies on the two EF-hand calcium-binding sites". Biochem. Biophys. Res. Commun. 260 (1): 1–8. doi:10.1006/bbrc.1999.0867. PMID 10381334.
- Taniguchi N, Taniura H, Niinobe M, et al. (2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. PMID 10915798.
- Nesselhut J, Jurgan U, Onken E, et al. (2002). "Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region". FEBS Lett. 509 (3): 469–75. doi:10.1016/S0014-5793(01)03187-8. PMID 11749975.
- Linē A, Stengrēvics A, Slucka Z, et al. (2002). "Serological identification and expression analysis of gastric cancer-associated genes". Br. J. Cancer 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Islam A, Adamik B, Hawari FI, et al. (2006). "Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex". J. Biol. Chem. 281 (10): 6860–73. doi:10.1074/jbc.M509397200. PMID 16407280.
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