Nucleoplasmin
Nucleoplasmin, the first identified molecular chaperone[1] is a thermostable acidic protein with a pentameric structure. The protein was first isolated from Xenopus species[2][3][4]
Functions
The pentameric protein participates in various significant cellular activities like sperm chromatin remodeling, nucleosome assembly, genome stability, ribosome biogenesis, DNA duplication and transcriptional regulation.[4][5] During the assembly of regular nucleosomal arrays, these nucleoplasmins transfer the DNA to them by binding to the histones. This reaction requires ATP.[2][6][7][8]
References
- ↑ C, Dingwall; RA., Laskey (Feb 1990). "Nucleoplasmin: the archetypal molecular chaperone.". Seminars in Cell Biology 1 (1). pp. 11–17.
- 1 2 "Nucleoplasmin-Mediated Decondensation of Mytilus Sperm Chromatin. Identification and Partial Characterization of a Nucleoplasmin-like Protein with Sperm-Nuclei Decondensing Activity in Mytilus californianus". Biochemistry. 34(23). ACS publications. June 1995. pp. 7563–7568. doi:10.1021/bi00023a001.
- ↑ "A polypeptide domain that specifies migration of nucleoplasmin into the nucleus". Cell 30 (2): 449–458. September 1982. doi:10.1016/0092-8674(82)90242-2. PMID 6814762.
- 1 2 Jun, SHUTe; Zhou, ZHANGYao (2007). "Nucleoplasmin, an Important Nuclear Chaperone". Chinese Journal of Biochemistry and Molecular Biol 23 (9): 718–723.
- ↑ J. Frehlick, Lindsay et al. (January 2007). "New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperones". BioEssays 29 (1). pp. 49–59. doi:10.1002/bies.20512.
- ↑ "InterPro annotation". Superfamily 1.75, HMM Library and Genome Assignment Server.
- ↑ Ramos, Isbaal et al. (2013). "The intrinsically disordered distal face of nucleoplasmin recognizes distinct oligomerization states of histones". Nucleic Acids Research. doi:10.1093/nar/gkt899.
- ↑ "InterPro". EMBL-EBI, Wellcome Trust Genome Campus,European Molecular Biology Laboratory.
Further reading
- Philpott, Anna, and Gregory H. Leno. "Nucleoplasmin remodels sperm chromatin in Xenopus egg extracts." Cell 69.5 (1992): 759-767.
- Laskey, R. A. et al. "The Role of Nucleoplasmin in Chromatin Assembly and Disassembly". Philosophical Transactions: Biological Sciences 339 (1289). The Royal Society. pp. 263–269. doi:10.1098/rstb.1993.0024.
- Dingwall, C., and R. A. Laskey. "Nucleoplasmin: the archetypal molecular chaperone." Seminars in cell biology. Vol. 1. No. 1. 1990.
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