O-aminophenol oxidase

O-aminophenol oxidase
Identifiers
EC number	1.10.3.4
CAS number	9013-85-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

O-aminophenol oxidase (EC 1.10.3.4, isophenoxazine synthase, o-aminophenol:O₂ oxidoreductase, 2-aminophenol:O₂ oxidoreductase, GriF) is an enzyme with systematic name 2-aminophenol:oxygen oxidoreductase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

2 2-aminophenol + O₂ + acceptor $\rightleftharpoons$ 2-aminophenoxazin-3-one + reduced acceptor + 2 H₂O (overall reaction)

(1a) 2 2-aminophenol + O₂ $\rightleftharpoons$ 2 6-iminocyclohexa-2,4-dienone + 2 H₂O

(1b) 2 6-iminocyclohexa-2,4-dienone + acceptor $\rightleftharpoons$ 2-aminophenoxazin-3-one + reduced acceptor (spontaneous)

O-aminophenol oxidase is a flavoprotein.

References

1. Nair, P.M. and Vaidynathan, C.S. (1964). "Isophenoxazine synthase". Biochim. Biophys. Acta 81: 507–516. doi:10.1016/0926-6569(64)90135-x. PMID 14170322.
2. Nair, P.M. and Vining, L.C. (1965). "Isophenoxazine synthase apoenzyme from Pycnoporus coccineus". Biochim. Biophys. Acta 96: 318–327. doi:10.1016/0926-6593(65)90015-9. PMID 14298835.
3. Subba Rao, P.V. and Vaidyanathan, C.S. (1967). "Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra". Arch. Biochem. Biophys. 118 (2): 388–394. doi:10.1016/0003-9861(67)90365-7. PMID 4166439.
4. Suzuki, H., Furusho, Y., Higashi, T., Ohnishi, Y. and Horinouchi, S. (2006). "A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone". J. Biol. Chem. 281 (2): 824–833. doi:10.1074/jbc.M505806200. PMID 16282322.

External links

• O-aminophenol oxidase at the US National Library of Medicine Medical Subject Headings (MeSH)