OAS1

2'-5'-oligoadenylate synthetase 1, 40/46kDa
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4IG8​
Identifiers
Symbols	OAS1 ; IFI-4; OIAS; OIASI
External IDs	OMIM: 164350 HomoloGene: 1903 GeneCards: OAS1 Gene
EC number	2.7.7.84
Gene ontology Molecular function • 2'-5'-oligoadenylate synthetase activity • double-stranded RNA binding • protein binding • ATP binding • zinc ion binding • metal ion binding Cellular component • extracellular region • nucleus • cytoplasm • mitochondrion • endoplasmic reticulum • cytosol Biological process • glucose metabolic process • purine nucleotide biosynthetic process • response to virus • cytokine-mediated signaling pathway • cellular response to interferon-alpha • glucose homeostasis • negative regulation of viral genome replication • protein oligomerization • defense response to virus • interferon-gamma-mediated signaling pathway • type I interferon signaling pathway • regulation of ribonuclease activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4938	23960
Ensembl	ENSG00000089127	ENSMUSG00000066861
UniProt	P00973	P11928
RefSeq (mRNA)	NM_001032409	NM_011852
RefSeq (protein)	NP_001027581	NP_035982
Location (UCSC)	Chr 12: 112.91 – 112.93 Mb	Chr 5: 120.88 – 120.89 Mb
PubMed search

2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene.^[1][2]

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in both viral and endogenous RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.^[3]

References

1. Renault B, Hovnanian A, Bryce S, Chang JJ, Lau S, Sakuntabhai A, Monk S, Carter S, Ross CJ, Pang J, Twells R, Chamberlain S, Monaco AP, Strachan T, Kucherlapati R (Feb 1998). "A sequence-ready physical map of a region of 12q24.1". Genomics 45 (2): 271–8. doi:10.1006/geno.1997.4888. PMID 9344649.
2. Nechiporuk T, Nechiporuk A, Sahba S, Figueroa K, Shibata H, Chen XN, Korenberg JR, de Jong P, Pulst SM (Nov 1997). "A high-resolution PAC and BAC map of the SCA2 region". Genomics 44 (3): 321–9. doi:10.1006/geno.1997.4886. PMID 9325053.
3. "Entrez Gene: OAS1 2',5'-oligoadenylate synthetase 1, 40/46kDa".

Further reading

• Justesen J, Hartmann R, Kjeldgaard NO (2000). "Gene structure and function of the 2'-5'-oligoadenylate synthetase family.". Cell. Mol. Life Sci. 57 (11): 1593–612. doi:10.1007/PL00000644. PMID 11092454.
• Ghosh SK, Kusari J, Bandyopadhyay SK, et al. (1991). "Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships.". J. Biol. Chem. 266 (23): 15293–9. PMID 1651324.
• Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
• Saunders ME, Gewert DR, Tugwell ME, et al. (1985). "Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure.". EMBO J. 4 (7): 1761–8. PMC 554415. PMID 2411547.
• Benech P, Mory Y, Revel M, Chebath J (1986). "Structure of two forms of the interferon-induced (2'-5') oligo A synthetase of human cells based on cDNAs and gene sequences.". EMBO J. 4 (9): 2249–56. PMC 554493. PMID 2416561.
• Williams BR, Saunders ME, Willard HF (1986). "Interferon-regulated human 2-5A synthetase gene maps to chromosome 12.". Somat. Cell Mol. Genet. 12 (4): 403–8. doi:10.1007/BF01570735. PMID 2426799.
• Hovanessian AG, Laurent AG, Chebath J, et al. (1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.". EMBO J. 6 (5): 1273–80. PMC 553929. PMID 2440675.
• Rutherford MN, Hannigan GE, Williams BR (1988). "Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene.". EMBO J. 7 (3): 751–9. PMC 454386. PMID 2456211.
• Benech P, Vigneron M, Peretz D, et al. (1988). "Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene.". Mol. Cell. Biol. 7 (12): 4498–504. PMC 368134. PMID 2830497.
• Wathelet MG, Clauss IM, Nols CB, et al. (1988). "New inducers revealed by the promoter sequence analysis of two interferon-activated human genes.". Eur. J. Biochem. 169 (2): 313–21. doi:10.1111/j.1432-1033.1987.tb13614.x. PMID 3121313.
• Wathelet MG, Szpirer J, Nols CB, et al. (1988). "Cloning and chromosomal location of human genes inducible by type I interferon.". Somat. Cell Mol. Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763.
• Wathelet M, Moutschen S, Cravador A, et al. (1986). "Full-length sequence and expression of the 42 kDa 2-5A synthetase induced by human interferon.". FEBS Lett. 196 (1): 113–20. doi:10.1016/0014-5793(86)80224-1. PMID 3753689.
• Shiojiri S, Fukunaga R, Ichii Y, Sokawa Y (1986). "Structure and expression of a cloned cDNA for human (2'-5')oligoadenylate synthetase.". J. Biochem. 99 (5): 1455–64. PMID 3754863.
• Merlin G, Chebath J, Benech P, et al. (1983). "Molecular cloning and sequence of partial cDNA for interferon-induced (2'-5')oligo(A) synthetase mRNA from human cells.". Proc. Natl. Acad. Sci. U.S.A. 80 (16): 4904–8. doi:10.1073/pnas.80.16.4904. PMC 384155. PMID 6348777.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ghosh A, Sarkar SN, Guo W, et al. (1998). "Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein.". J. Biol. Chem. 272 (52): 33220–6. doi:10.1074/jbc.272.52.33220. PMID 9407111.
• Hovnanian A, Rebouillat D, Mattei MG, et al. (1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms.". Genomics 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745.
• Sarkar SN, Ghosh A, Wang HW, et al. (1999). "The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases.". J. Biol. Chem. 274 (36): 25535–42. doi:10.1074/jbc.274.36.25535. PMID 10464285.