OAS3

2'-5'-oligoadenylate synthetase 3, 100kDa
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4S3N​
Identifiers
Symbols	OAS3 ; p100; p100OAS
External IDs	OMIM: 603351 MGI: 2180850 HomoloGene: 4510 GeneCards: OAS3 Gene
EC number	2.7.7.84
Gene ontology Molecular function • 2'-5'-oligoadenylate synthetase activity • double-stranded RNA binding • protein binding • ATP binding • metal ion binding Cellular component • extracellular space • nucleoplasm • cytoplasm • cytosol • plasma membrane • intracellular membrane-bounded organelle Biological process • nucleobase-containing compound metabolic process • response to virus • cytokine-mediated signaling pathway • negative regulation of viral genome replication • defense response to virus • interferon-gamma-mediated signaling pathway • type I interferon signaling pathway • regulation of ribonuclease activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4940	246727
Ensembl	ENSG00000111331	ENSMUSG00000032661
UniProt	Q9Y6K5	Q8VI93
RefSeq (mRNA)	NM_006187	NM_145226
RefSeq (protein)	NP_006178	NP_660261
Location (UCSC)	Chr 12: 112.94 – 112.97 Mb	Chr 5: 120.75 – 120.78 Mb
PubMed search

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.^[1][2]

This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of ATP. These oligos activate latent RNase L, leading to degradation of both viral and endogenous RNA. This enzyme family plays a significant role in the inhibition of cellular protein synthesis in response to viral infection.^[2]

References

1. Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745.
2. "Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa".

Further reading

• Hovanessian AG, Justesen J (2007). "The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.". Biochimie 89 (6-7): 779–88. doi:10.1016/j.biochi.2007.02.003. PMID 17408844.
• Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes.". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
• Hovanessian AG, Laurent AG, Chebath J, et al. (1987). "Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies.". EMBO J. 6 (5): 1273–80. PMC 553929. PMID 2440675.
• Marié I, Blanco J, Rebouillat D, Hovanessian AG (1997). "69-kDa and 100-kDa isoforms of interferon-induced (2'-5')oligoadenylate synthetase exhibit differential catalytic parameters.". Eur. J. Biochem. 248 (2): 558–66. doi:10.1111/j.1432-1033.1997.t01-1-00558.x. PMID 9346316.
• Rebouillat D, Hovnanian A, Marié I, Hovanessian AG (1999). "The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains.". J. Biol. Chem. 274 (3): 1557–65. doi:10.1074/jbc.274.3.1557. PMID 9880533.
• Rebouillat D, Hovnanian A, David G, et al. (2001). "Characterization of the gene encoding the 100-kDa form of human 2',5' oligoadenylate synthetase.". Genomics 70 (2): 232–40. doi:10.1006/geno.2000.6382. PMID 11112351.
• Ito M, Shichijo S, Tsuda N, et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells.". Cancer Res. 61 (5): 2038–46. PMID 11280764.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12.". Nature 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.