OBSL1

Obscurin-like 1
PDB rendering based on 2cpc.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2CPC​, 2E6P​, 2E6Q​, 2LU7​, 2LVC​, 2WP3​, 2WWK​, 2WWM​, 3KNB​
Identifiers
Symbols	OBSL1 ; KIAA0657; MGC71026
External IDs	OMIM: 610991 HomoloGene: 28013 GeneCards: OBSL1 Gene
EC number	2.7.11.18
Gene ontology Molecular function • protein binding • cytoskeletal adaptor activity Cellular component • cytoplasm • Golgi apparatus • centrosome • intercalated disc • Z disc • M band • perinuclear region of cytoplasm • 3M complex Biological process • microtubule cytoskeleton organization • cytoskeleton organization • Golgi organization • regulation of mitotic nuclear division • protein localization to Golgi apparatus • positive regulation of dendrite morphogenesis • cardiac myofibril assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23363	98733
Ensembl	ENSG00000124006	ENSMUSG00000026211
UniProt	O75147	D3YYU8
RefSeq (mRNA)	NM_001173408	NM_178884
RefSeq (protein)	NP_001166879	NP_849215
Location (UCSC)	Chr 2: 219.55 – 219.57 Mb	Chr 1: 75.48 – 75.51 Mb
PubMed search

Obscurin-like protein 1 is a protein that in humans is encoded by the OBSL1 gene.^[1][2]

References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
2. "Entrez Gene: OBSL1 obscurin-like 1".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Geisler SB, Robinson D, Hauringa M, et al. (2007). "Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin.". Genomics 89 (4): 521–31. doi:10.1016/j.ygeno.2006.12.004. PMC 1885211. PMID 17289344.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

External links

• GeneReviews/NIH/NCBI/UW entry on 3-M syndrome
• OMIM entries on 3-M syndrome