ODZ1

Teneurin transmembrane protein 1
Identifiers
Symbols	TENM1 ; ODZ1; ODZ3; TEN-M1; TNM; TNM1
External IDs	OMIM: 300588 MGI: 1345185 HomoloGene: 56542 GeneCards: TENM1 Gene
Gene ontology Molecular function • heparin binding • protein homodimerization activity • protein heterodimerization activity Cellular component • extracellular region • nucleus • cytoplasm • endoplasmic reticulum • Golgi apparatus • cytoskeleton • plasma membrane • integral component of plasma membrane • nuclear matrix • nuclear speck • perinuclear region of cytoplasm Biological process • transcription, DNA-templated • regulation of transcription from RNA polymerase III promoter • immune response • neuropeptide signaling pathway • nervous system development • negative regulation of cell proliferation • positive regulation of actin filament polymerization • positive regulation of peptidyl-serine phosphorylation • positive regulation of MAP kinase activity • positive regulation of filopodium assembly • positive regulation of intracellular protein transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10178	23963
Ensembl	ENSG00000009694	ENSMUSG00000016150
UniProt	Q9UKZ4	Q9WTS4
RefSeq (mRNA)	NM_001163278	NM_011855
RefSeq (protein)	NP_001156750	NP_035985
Location (UCSC)	Chr X: 124.38 – 124.96 Mb	Chr X: 42.53 – 43.43 Mb
PubMed search

Teneurin-1 is a protein that in humans is encoded by the ODZ1 gene.^[1][2][3]This protein belongs to a family of similar teneurins.

References

1. Ben-Zur T, Wides R (Jul 1999). "Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25". Genomics 58 (1): 102–3. doi:10.1006/geno.1999.5798. PMID 10331952.
2. Minet AD, Rubin BP, Tucker RP, Baumgartner S, Chiquet-Ehrismann R (Aug 1999). "Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain". J Cell Sci 112 (12): 2019–32. PMID 10341219.
3. "Entrez Gene: ODZ1 odz, odd Oz/ten-m homolog 1(Drosophila)".

Further reading

• Coffey AJ, Brooksbank RA, Brandau O, et al. (1998). "Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene.". Nat. Genet. 20 (2): 129–35. doi:10.1038/2424. PMID 9771704.
• Brandau O, Schuster V, Weiss M, et al. (2000). "Epstein-Barr virus-negative boys with non-Hodgkin lymphoma are mutated in the SH2D1A gene, as are patients with X-linked lymphoproliferative disease (XLP).". Hum. Mol. Genet. 8 (13): 2407–13. doi:10.1093/hmg/8.13.2407. PMID 10556288.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Feng K, Zhou XH, Oohashi T, et al. (2002). "All four members of the Ten-m/Odz family of transmembrane proteins form dimers.". J. Biol. Chem. 277 (29): 26128–35. doi:10.1074/jbc.M203722200. PMID 12000766.
• Zhou XH, Brandau O, Feng K, et al. (2004). "The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.". Gene Expr. Patterns 3 (4): 397–405. doi:10.1016/S1567-133X(03)00087-5. PMID 12915301.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Nunes SM, Ferralli J, Choi K, et al. (2005). "The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix.". Exp. Cell Res. 305 (1): 122–32. doi:10.1016/j.yexcr.2004.12.020. PMID 15777793.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• ODZ1 human gene location in the UCSC Genome Browser.
• ODZ1 human gene details in the UCSC Genome Browser.