ODZ4
| Teneurin transmembrane protein 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | TENM4 ; Doc4; ODZ4; TNM4; Ten-M4 | ||||||||||||
| External IDs | OMIM: 610084 HomoloGene: 8034 GeneCards: TENM4 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 26011 | 23966 | |||||||||||
| Ensembl | ENSG00000149256 | ENSMUSG00000048078 | |||||||||||
| UniProt | Q6N022 | Q3UHK6 | |||||||||||
| RefSeq (mRNA) | NM_001098816 | NM_011858 | |||||||||||
| RefSeq (protein) | NP_001092286 | NP_035988 | |||||||||||
| Location (UCSC) |
Chr 11: 78.65 – 79.44 Mb |
Chr 7: 96.17 – 96.91 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein Odd Oz/ten-m homolog 4 also known as teneurin-4 (Ten-4) and tenascin-M4 (Ten-m4) is a protein that in humans is encoded by the ODZ4 gene.[1] This protein belongs to a family of similar teneurins.
Disease linkage
ODZ4 is involved in the polygenic character of the bipolar disorder.[2]
References
- ↑ "Entrez Gene: Odz, odd Oz/ten-m homolog 4 (Drosophila)". Retrieved 2012-05-02.
- ↑ Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, Mattheisen M, Forstner AJ, Schumacher J, Breuer R, Meier S, Herms S, Hoffmann P, Lacour A, Witt SH, Reif A, Müller-Myhsok B, Lucae S, Maier W, Schwarz M, Vedder H, Kammerer-Ciernioch J, Pfennig A, Bauer M, Hautzinger M, Moebus S, Priebe L, Czerski PM, Hauser J, Lissowska J, Szeszenia-Dabrowska N, Brennan P, McKay JD, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Krasnow V, Chuchalin A, Babadjanova G, Pantelejeva G, Abramova LI, Tiganov AS, Polonikov A, Khusnutdinova E, Alda M, Grof P, Rouleau GA, Turecki G, Laprise C, Rivas F, Mayoral F, Kogevinas M, Grigoroiu-Serbanescu M, Propping P, Becker T, Rietschel M, Nöthen MM, Cichon S (2014). "Genome-wide association study reveals two new risk loci for bipolar disorder". Nature Communications 5: 3339. doi:10.1038/ncomms4339. PMID 24618891.
Further reading
- Ben-Zur T, Feige E, Motro B, Wides R (Jan 2000). "The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles". Developmental Biology 217 (1): 107–120. doi:10.1006/dbio.1999.9532. PMID 10625539.
- Docherty SJ, Kovas Y, Petrill SA, Plomin R (2010). "Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities". BMC Genetics 11: 61. doi:10.1186/1471-2156-11-61. PMC 2909150. PMID 20602751.
- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y (Mar 2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
- Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser AS, Kelly-Hayes M, Kase CS, D'Agostino RB, Decarli C, Atwood LD, Wolf PA (2007). "Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study". BMC Medical Genetics. 8 Suppl 1: S15. doi:10.1186/1471-2350-8-S1-S15. PMC 1995608. PMID 17903297.
- "Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4". Nature Genetics 43 (10): 977–983. Oct 2011. doi:10.1038/ng.943. PMC 3637176. PMID 21926972.
- Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, MacLean AW, St CD, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N (Sep 2008). "Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder". Nature Genetics 40 (9): 1056–1058. doi:10.1038/ng.209. PMC 2703780. PMID 18711365.
- Feng K, Zhou XH, Oohashi T, Mörgelin M, Lustig A, Hirakawa S, Ninomiya Y, Engel J, Rauch U, Fässler R (Jul 2002). "All four members of the Ten-m/Odz family of transmembrane proteins form dimers". The Journal of Biological Chemistry 277 (29): 26128–26135. doi:10.1074/jbc.M203722200. PMID 12000766.
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