OK cells

OK cells (short for opossum kidney cells) are a marsupial cell line used in research to model proximal tubule epithelial cells of the kidney. The cell line was derived from the kidney of an adult female North American opossum (Didelphis virginiana).[1] Like porcine LLC-PK1 cells, this cell line has the limitation of lacking several enzymes specific to the proximal tubule.[2] Nonetheless, OK cells have been used extensively to study functional interactions between the parathyroid hormone 1 receptor (PTH1R) and the sodium-hydrogen exchange regulatory factor 1 (NHERF1).[3]

OK cells were originally cultured as a source of X chromosomes for studies on X inactivation.[1] OK cells are sold under the trade name CRL-1840 by ATCC.

References

  1. 1 2 Koyama, H.; Goodpasture, C.; Miller, M. M.; Teplitz, R. L.; Riggs, A. D. (March 1978). "Establishment and characterization of a cell line from the american opossum (Didelphys virginiana)". In Vitro 14 (3): 239–246. doi:10.1007/BF02616032.
  2. ↑ Kruidering, Marieke; Water, Bob van der; Nagelkerke, J. Fred (1996). "Methods for Studying Renal Toxicity". Archives of Toxicology 18: 173-183. doi:10.1007/978-3-642-61105-6.
  3. ↑ Ciruela, Francisco; Luján, Rafael (2008). Molecular Aspects of G Protein-Coupled Receptors: Interacting Proteins and Function. New York, NY: Nova Science Publishers. p. 219.

External links

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